Literature DB >> 30275207

Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol.

Julian Kenyon1, Wai Liu2, Angus Dalgleish2.   

Abstract

BACKGROUND/AIM: Cannabinoids are widely used in the management of pain, nausea and cachexia in cancer patients. However, there has been no objective clinical evidence of any anticancer activity yet. The aim of this study was to assess the effects of pharmaceutical-grade synthetic cannabidiol on a range of cancer patients. PATIENTS AND METHODS: We analysed the data routinely collected, as part of our treatment program, in 119 cancer patients over a four-year period.
RESULTS: Clinical responses were seen in 92% of the 119 cases with solid tumours including a reduction in circulating tumour cells in many cases and in other cases, a reduction in tumour size, as shown by repeat scans. No side-effects of any kind were observed when using pharmaceutical grade synthetic cannabidiol.
CONCLUSION: Pharmaceutical-grade synthetic cannabidiol is a candidate for treating breast cancer and glioma patients. Copyright
© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Entities:  

Keywords:  Cancer; breast cancer; cannabinoids; ependymoma; prostate cancer

Mesh:

Substances:

Year:  2018        PMID: 30275207     DOI: 10.21873/anticanres.12924

Source DB:  PubMed          Journal:  Anticancer Res        ISSN: 0250-7005            Impact factor:   2.480


  22 in total

1.  Management of Concomitant Abdominal Aortic Aneurysm and Intra-abdominal, Retroperitoneal Malignancy.

Authors:  Vladislav Treska; Jiri Molacek; Bohuslav Certik; Karel Houdek; Petr Hosek; Veronika Soukupova; Christiana Stogerova; Aneta Svejdova
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.155

2.  Neuropharmacological Effects of the Main Phytocannabinoids: A Narrative Review.

Authors:  Rafael G Dos Santos; Jaime E C Hallak; José Alexandre S Crippa
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

3.  Cannabidiol Interacts Antagonistically with Cisplatin and Additively with Mitoxantrone in Various Melanoma Cell Lines-An Isobolographic Analysis.

Authors:  Paweł Marzęda; Paula Wróblewska-Łuczka; Małgorzata Drozd; Magdalena Florek-Łuszczki; Katarzyna Załuska-Ogryzek; Jarogniew J Łuszczki
Journal:  Int J Mol Sci       Date:  2022-06-17       Impact factor: 6.208

Review 4.  [Cannabidiol in cancer treatment].

Authors:  Rudolf Likar; Markus Köstenberger; Gerhard Nahler
Journal:  Schmerz       Date:  2020-04       Impact factor: 1.107

5.  The perceptions and beliefs of cannabis use among Canadian genitourinary cancer patients.

Authors:  Shipra Taneja; Yanbo Guo; Marissa Slaven; Aly-Khan Lalani; Erynn Shaw; Camilla Tajzler; Sebastien Hotte; Anil Kapoor
Journal:  Can Urol Assoc J       Date:  2022-02       Impact factor: 1.862

6.  Cannabidiol inhibits sucrose self-administration by CB1 and CB2 receptor mechanisms in rodents.

Authors:  Guo-Hua Bi; Ewa Galaj; Yi He; Zheng-Xiong Xi
Journal:  Addict Biol       Date:  2019-06-19       Impact factor: 4.093

Review 7.  Cannabis as an Anticancer Agent: A Review of Clinical Data and Assessment of Case Reports.

Authors:  Jordan Guggisberg; Megan Schumacher; Grace Gilmore; Dylan M Zylla
Journal:  Cannabis Cannabinoid Res       Date:  2021-08-07

8.  Cannabidiol loaded extracellular vesicles sensitize triple-negative breast cancer to doxorubicin in both in-vitro and in vivo models.

Authors:  Nilkumar Patel; Nagavendra Kommineni; Sunil Kumar Surapaneni; Anil Kalvala; Xuegang Yaun; Aragaw Gebeyehu; Peggy Arthur; Leanne C Duke; Sara B York; Arvind Bagde; David G Meckes; Mandip Singh
Journal:  Int J Pharm       Date:  2021-07-27       Impact factor: 6.510

Review 9.  Cannabinoids as anticancer drugs: current status of preclinical research.

Authors:  Burkhard Hinz; Robert Ramer
Journal:  Br J Cancer       Date:  2022-03-11       Impact factor: 9.075

Review 10.  Use of cannabis in urological cancer patients: A review to evaluate risk for cancer development, therapeutic use, and symptom management.

Authors:  Shipra Taneja; Jen Hoogenes; Marissa Slaven; Anil Kapoor
Journal:  Can Urol Assoc J       Date:  2021-12       Impact factor: 1.862

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