Shipra Taneja1,2,3, Jen Hoogenes1,2,3, Marissa Slaven4,5, Anil Kapoor1,2,3,4. 1. Department of Surgery, Division of Urology, McMaster University, Hamilton, ON, Canada. 2. McMaster Institute of Urology, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. 3. Urologic Cancer Centre for Research & Innovation, St. Joseph's Healthcare, Hamilton, ON Canada. 4. Juravinski Cancer Centre, Juravinski Hospital, Hamilton, ON, Canada. 5. Department of Family Medicine, McMaster University, Hamilton, ON, Canada.
Abstract
INTRODUCTION: Recent recreational legalization of cannabis has resulted in an increased interest in the therapeutic effects of cannabis use in cancer patients, with reports of its use in symptom management and as a risk factor for cancer development. The objective of this review was to evaluate the literature on the association of cannabis use with the risk of cancer development, symptom management, and therapeutic management in the urological cancer (UC) patient population. METHODS: A systematic search of databases and trial registries for papers published from January 1947 to March 2020 on cannabis, symptom and therapeutic management, and cancer development in UC patients was conducted. After screening of full-text articles, data were extracted for evaluation. Studies were eligible if they were in the clinical setting, included ≥5 UC patients, reported use of any cannabis variant, and were written in English. RESULTS: The search retrieved 2456 abstracts, of which 48 full-text articles were reviewed and 21 included in the review. Low-level evidence suggested a correlation between cannabis use and risk for development of testicular cancer. Some support existed for using cannabis for cancer pain and chemotherapy-induced nausea. There was inadequate evidence to substantiate cannabis use as a therapeutic agent for management of UCs. A lack of high-level evidence and robust methodology of the studies limited evaluation of the findings. CONCLUSIONS: Given the paucity of data on cannabis use for therapeutic purposes in UC, large, prospective trials with adequate followup times to observe the effect of cannabis use on UCs are warranted to improve the evidence base.
INTRODUCTION: Recent recreational legalization of cannabis has resulted in an increased interest in the therapeutic effects of cannabis use in cancer patients, with reports of its use in symptom management and as a risk factor for cancer development. The objective of this review was to evaluate the literature on the association of cannabis use with the risk of cancer development, symptom management, and therapeutic management in the urological cancer (UC) patient population. METHODS: A systematic search of databases and trial registries for papers published from January 1947 to March 2020 on cannabis, symptom and therapeutic management, and cancer development in UC patients was conducted. After screening of full-text articles, data were extracted for evaluation. Studies were eligible if they were in the clinical setting, included ≥5 UC patients, reported use of any cannabis variant, and were written in English. RESULTS: The search retrieved 2456 abstracts, of which 48 full-text articles were reviewed and 21 included in the review. Low-level evidence suggested a correlation between cannabis use and risk for development of testicular cancer. Some support existed for using cannabis for cancer pain and chemotherapy-induced nausea. There was inadequate evidence to substantiate cannabis use as a therapeutic agent for management of UCs. A lack of high-level evidence and robust methodology of the studies limited evaluation of the findings. CONCLUSIONS: Given the paucity of data on cannabis use for therapeutic purposes in UC, large, prospective trials with adequate followup times to observe the effect of cannabis use on UCs are warranted to improve the evidence base.
Authors: Anil A Thomas; Lauren P Wallner; Virginia P Quinn; Jeffrey Slezak; Stephen K Van Den Eeden; Gary W Chien; Steven J Jacobsen Journal: Urology Date: 2014-11-01 Impact factor: 2.649
Authors: Aron H Lichtman; Eberhard Albert Lux; Robert McQuade; Sandro Rossetti; Raymond Sanchez; Wei Sun; Stephen Wright; Elena Kornyeyeva; Marie T Fallon Journal: J Pain Symptom Manage Date: 2017-09-18 Impact factor: 3.612
Authors: Ilana M Braun; Alexi Wright; John Peteet; Fremonta L Meyer; David P Yuppa; Dragana Bolcic-Jankovic; Jessica LeBlanc; Yuchiao Chang; Liyang Yu; Manan M Nayak; James A Tulsky; Joji Suzuki; Lida Nabati; Eric G Campbell Journal: J Clin Oncol Date: 2018-05-10 Impact factor: 44.544