Rosa E Pérez-Morales1, María Dolores Del Pino2, José Manuel Valdivielso3,4, Alberto Ortiz4,5,6, Carmen Mora-Fernández4,6,7, Juan F Navarro-González8,9,10,11. 1. Servicio de Nefrología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. 2. Servicio de Nefrología, Hospital Torrecárdenas, Almería, Spain. 3. Grupo de Investigación Traslacional Vascular y Renal, Instituto de Investigación Biomédica IRBLLEIDA, Lleida, Spain. 4. Red de Investigación Renal (REDINREN), Instituto de Salud Carlos III, Madrid, Spain. 5. Instituto de Investigación Sanitaria-Fundación Jiménez Díaz-Universidad Autónoma de Madrid y Fundación Renal Iñigo Álvarez de Toledo-Instituto Reina Sofía de Investigación Nefrológica, Madrid, Spain. 6. GEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología, Spain. 7. Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain. 8. Servicio de Nefrología, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain, jnavgon@gobiernodecanarias.org. 9. Red de Investigación Renal (REDINREN), Instituto de Salud Carlos III, Madrid, Spain, jnavgon@gobiernodecanarias.org. 10. GEENDIAB (Grupo Español para el Estudio de la Nefropatía Diabética), Sociedad Española de Nefrología, Spain, jnavgon@gobiernodecanarias.org. 11. Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain, jnavgon@gobiernodecanarias.org.
Abstract
BACKGROUND: Diabetes is a growing public health problem. Diabetic kidney disease (DKD) is the most prevalent chronic renal disease and the major cause of end-stage renal failure worldwide, predominantly due to the increase of Type 2 diabetes associated with obesity. The intimate mechanisms leading to the development and progression of renal injury in DKD are not well understood, but current knowledge indicates that its pathogenesis is multifactorial, where the immune response and inflammation appear to be relevant factors. SUMMARY: This review summarizes the role of relevant inflammatory molecules and pathways that participate in the development of DKD. Likewise, we focused on the new therapeutic approaches based on anti-inflammatory effects of different drugs. Key Messages: This new pathogenic perspective of DKD as an inflammatory condition leads to novel horizons, such as the potential role of inflammatory signaling pathways and their downstream products as emerging biomarkers and promising therapeutic targets.
BACKGROUND:Diabetes is a growing public health problem. Diabetic kidney disease (DKD) is the most prevalent chronic renal disease and the major cause of end-stage renal failure worldwide, predominantly due to the increase of Type 2 diabetes associated with obesity. The intimate mechanisms leading to the development and progression of renal injury in DKD are not well understood, but current knowledge indicates that its pathogenesis is multifactorial, where the immune response and inflammation appear to be relevant factors. SUMMARY: This review summarizes the role of relevant inflammatory molecules and pathways that participate in the development of DKD. Likewise, we focused on the new therapeutic approaches based on anti-inflammatory effects of different drugs. Key Messages: This new pathogenic perspective of DKD as an inflammatory condition leads to novel horizons, such as the potential role of inflammatory signaling pathways and their downstream products as emerging biomarkers and promising therapeutic targets.
Authors: Luciana C Veiras; Ellen A Bernstein; DuoYao Cao; Derick Okwan-Duodu; Zakir Khan; David R Gibb; Arantxa Roach; Rachel Skelton; Ryan M Williams; Kenneth E Bernstein; Jorge F Giani Journal: Circ Res Date: 2022-05-16 Impact factor: 23.213