Literature DB >> 3027359

Glucocorticoid regulation of murine leukemia virus transcription elements is specified by determinants within the viral enhancer region.

D Celander, W A Haseltine.   

Abstract

The transcriptional control region (the long terminal repeat, LTR) of the leukemogenic murine retrovirus SL3-3 contains a glucocorticoid-responsive consensus sequence, as does the corresponding region of the nonleukemogenic virus Akv. Dexamethasone increases gene expression directed by both LTR sequences. However, the responses of the LTRs of the two viruses to dexamethasone differ according to the cell line in which the response is measured. The results of these studies provide insights regarding differences in response to glucocorticoids dependent upon cell line and indicate that the glucocorticoid-responsive elements may compose one of the determinants of tissue specificity and pathogenicity of the murine retroviruses.

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Year:  1987        PMID： 3027359      PMCID： PMC253946          DOI： 10.1128/JVI.61.2.269-275.1987

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

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Journal:  Adv Cancer Res       Date:  1979       Impact factor: 6.242

2.  DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo.

Authors:  V L Chandler; B A Maler; K R Yamamoto
Journal:  Cell       Date:  1983-06       Impact factor: 41.582

3.  The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection.

Authors:  C M Gorman; G T Merlino; M C Willingham; I Pastan; B H Howard
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205

4.  Two different factors act separately or together to specify functionally distinct activities at a single transcriptional enhancer.

Authors:  D DeFranco; K R Yamamoto
Journal:  Mol Cell Biol       Date:  1986-04       Impact factor: 4.272

5.  Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat.

Authors:  J Lenz; D Celander; R L Crowther; R Patarca; D W Perkins; W A Haseltine
Journal:  Nature       Date:  1984 Mar 29-Apr 4       Impact factor: 49.962

6.  Acquisition of proviral DNA of mouse mammary tumor virus in thymic leukemia cells from GR mice.

Authors:  R Michalides; E Wagenaar; J Hilkens; J Hilgers; B Groner; N E Hynes
Journal:  J Virol       Date:  1982-09       Impact factor: 5.103

7.  Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors:  C M Gorman; L F Moffat; B H Howard
Journal:  Mol Cell Biol       Date:  1982-09       Impact factor: 4.272

8.  Role for the 3' end of the genome in determining disease specificity of Friend and Moloney murine leukemia viruses.

Authors:  P A Chatis; C A Holland; J W Hartley; W P Rowe; N Hopkins
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

9.  Thymotropism of murine leukemia virus is conferred by its long terminal repeat.

Authors:  L DesGroseillers; E Rassart; P Jolicoeur
Journal:  Proc Natl Acad Sci U S A       Date:  1983-07       Impact factor: 11.205

10.  A new determinant of glucocorticoid sensitivity in lymphoid cell lines.

Authors:  J C Gasson; S Bourgeois
Journal:  J Cell Biol       Date:  1983-02       Impact factor: 10.539
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  18 in total

1.  Helix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancers.

Authors:  B Corneliussen; A Thornell; B Hallberg; T Grundström
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

2.  Control of pathogenicity and disease specificity of a T-lymphomagenic gammaretrovirus by E-box motifs but not by an overlapping glucocorticoid response element.

Authors:  Ditte Ejegod; Karina Dalsgaard Sørensen; Ilona Mossbrugger; Leticia Quintanilla-Martinez; Jörg Schmidt; Finn Skou Pedersen
Journal:  J Virol       Date:  2008-10-22       Impact factor: 5.103

3.  Enhancer functions in U3 of Akv virus: a role for cooperativity of a tandem repeat unit and its flanking DNA sequences.

Authors:  S Lovmand; N O Kjeldgaard; P Jørgensen; F S Pedersen
Journal:  J Virol       Date:  1990-07       Impact factor: 5.103

4.  CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes.

Authors:  A L Zaiman; A Nieves; J Lenz
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

5.  A correlation between dexamethasone inducibility and basal expression levels of retroviral vector proviruses.

Authors:  M Duch; K Paludan; J Lovmand; L Pedersen; P Jørgensen; F S Pedersen
Journal:  Nucleic Acids Res       Date:  1993-10-11       Impact factor: 16.971

6.  Ikaros, a lymphoid-cell-specific transcription factor, contributes to the leukemogenic phenotype of a mink cell focus-inducing murine leukemia virus.

Authors:  Nancy L DiFronzo; Cheuk T Leung; Mark K Mammel; Katia Georgopoulos; Barbara J Taylor; Quynh N Pham
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

7.  Pathogenic determinants in the U3 region of recombinant murine leukemia viruses isolated from CWD and HRS/J mice.

Authors:  S C Lawrenz-Smith; A C Massey; D J Innes; C Y Thomas
Journal:  J Virol       Date:  1994-08       Impact factor: 5.103

8.  Origins of enhancer sequences of recombinant murine leukemia viruses from spontaneous B- and T-cell lymphomas of CWD mice.

Authors:  A C Massey; S C Lawrenz-Smith; D J Innes; C Y Thomas
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

9.  Glucocorticoid-mediated immunomodulation: hydrocortisone enhances immunosuppressive endogenous retroviral protein (p15E) expression in mouse immune cells.

Authors:  M Fiegl; E Strasser-Wozak; S Geley; A Gsur; J Drach; R Kofler
Journal:  Clin Exp Immunol       Date:  1995-08       Impact factor: 4.330

10.  Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning.

Authors:  A L Nielsen; N Pallisgaard; F S Pedersen; P Jørgensen
Journal:  Mol Cell Biol       Date:  1992-08       Impact factor: 4.272
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