Reza Mohseni1, Soheil Abbasi2, Fatemeh Mohseni3, Fateme Rahimi2, Shahab Alizadeh4. 1. a Department of Community Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences (TUMS) , Tehran , Iran. 2. b Faculty of Public Health , Kermanshah University of Medical Science (KUMS) , Kermanshah , Iran. 3. c School of Medicine , Arak University of Medical Sciences , Arak , Iran. 4. d Department of Molecular Nutrition, School of Nutritional Sciences and Dietetics , Tehran University of Medical Sciences (TUMS) , Tehran , Iran.
Abstract
BACKGROUND: Diet is a known source of pro- and anti-inflammatory mediators, and inflammatory markers have been associated with mechanisms involved in prostate cancer initiation and progression. The Dietary Inflammatory Index (DII®) is a tool to assist researchers in determining the inflammatory potential of diet. The aim of this study was to conduct a meta-analysis to assess the association between DII and prostate cancer. METHODS: EMBASE and MEDLINE were searched from inception to February 2018, for relevant observational studies. The random effects model was used to calculate the overall relative risks (RRs) with 95% confidence intervals (CIs). RESULTS: Data from five case-control and one cohort study were eligible for inclusion. The adjusted pooled RR of prostate cancer for the highest (the most pro-inflammatory diet) versus lowest (the most anti-inflammatory diet) DII categories was 1.74 (95% CI: 1.24-2.43). The analysis in the DII score as a continuous variable was also performed and the results showed that the risk of prostate cancer was 9% higher for each one-point increase in the score. CONCLUSION: This meta-analysis suggests that promoting diets rich in anti-inflammatory food components (i.e., whole grains, fish, green vegetables, and fruits) should help in reducing preventing prostate cancer.
BACKGROUND: Diet is a known source of pro- and anti-inflammatory mediators, and inflammatory markers have been associated with mechanisms involved in prostate cancer initiation and progression. The Dietary Inflammatory Index (DII®) is a tool to assist researchers in determining the inflammatory potential of diet. The aim of this study was to conduct a meta-analysis to assess the association between DII and prostate cancer. METHODS: EMBASE and MEDLINE were searched from inception to February 2018, for relevant observational studies. The random effects model was used to calculate the overall relative risks (RRs) with 95% confidence intervals (CIs). RESULTS: Data from five case-control and one cohort study were eligible for inclusion. The adjusted pooled RR of prostate cancer for the highest (the most pro-inflammatory diet) versus lowest (the most anti-inflammatory diet) DII categories was 1.74 (95% CI: 1.24-2.43). The analysis in the DII score as a continuous variable was also performed and the results showed that the risk of prostate cancer was 9% higher for each one-point increase in the score. CONCLUSION: This meta-analysis suggests that promoting diets rich in anti-inflammatory food components (i.e., whole grains, fish, green vegetables, and fruits) should help in reducing preventing prostate cancer.
Authors: Catherine M Phillips; Ling-Wei Chen; Barbara Heude; Jonathan Y Bernard; Nicholas C Harvey; Liesbeth Duijts; Sara M Mensink-Bout; Kinga Polanska; Giulia Mancano; Matthew Suderman; Nitin Shivappa; James R Hébert Journal: Nutrients Date: 2019-08-12 Impact factor: 5.717