Hyo K Park1, Joellen M Schildkraut2, Anthony J Alberg3, Elisa V Bandera4, Jill S Barnholtz-Sloan5, Melissa Bondy6, Sydnee Crankshaw7, Ellen Funkhouser8, Patricia G Moorman7, Edward S Peters9, Paul Terry10, Frances Wang7, Julie J Ruterbusch11, Ann G Schwartz11, Michele L Cote11. 1. Department of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, 4100 John R. Mailcode: MM04EP, Detroit, MI, 48201, USA. hpar@med.wayne.edu. 2. Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA. 3. Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA. 4. Department of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. 5. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA. 6. Cancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX, USA. 7. Department of Community and Family Medicine, Cancer Control and Population Sciences, Duke University School of Medicine, Durham, NC, USA. 8. Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. 9. Epidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA, USA. 10. Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA. 11. Department of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, 4100 John R. Mailcode: MM04EP, Detroit, MI, 48201, USA.
Abstract
BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women. METHODS: Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer. RESULTS: 600 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between 1 December 2010 and 31 December 2015 comprised the study population. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.78; 95% CI 1.09-2.90). A non-significant association of similar magnitude was observed with PID (OR 1.33; 95% CI 0.82-2.16), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p = 0.006) with consistency across histologic subtypes and among both oral contraceptive users and non-users. CONCLUSION: A self-reported history of endometriosis among African-American women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions also increased ovarian cancer risk.
BACKGROUND: The association between common benign gynecologic conditions and ovarian cancer remains under-studied in African Americans. Therefore, we examine the association between self-reported history of benign gynecologic conditions and epithelial ovarian cancer risk in African-American women. METHODS: Data from a large population-based, multi-center case-control study of epithelial ovarian cancer in African-American women were analyzed to estimate the association between self-reported history of endometriosis, pelvic inflammatory disease (PID), fibroid, and ovarian cyst with epithelial ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for the associations between individual and composite gynecologic conditions and ovarian cancer. RESULTS: 600 cases and 752 controls enrolled in the African American Cancer Epidemiology Study between 1 December 2010 and 31 December 2015 comprised the study population. After adjusting for potential confounders, a history of endometriosis was associated with ovarian cancer (OR 1.78; 95% CI 1.09-2.90). A non-significant association of similar magnitude was observed with PID (OR 1.33; 95% CI 0.82-2.16), while no association was observed in women with a history of fibroid or ovarian cyst. A positive trend was observed for an increasing number of reported gynecologic conditions (p = 0.006) with consistency across histologic subtypes and among both oral contraceptive users and non-users. CONCLUSION: A self-reported history of endometriosis among African-American women was associated with increased risk of ovarian cancer. Having multiple benign gynecologic conditions also increased ovarian cancer risk.
Entities:
Keywords:
African-American; African-American Cancer Epidemiology Study (AACES); Endometriosis; Ovarian cancer; Ovarian cyst; Pelvic inflammatory disease (PID); Uterine fibroid
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