OBJECTIVE: To assess whether tubal ligation and hysterectomy affect subsequent risk of ovarian cancer. DESIGN: Prospective cohort study with 12 years of follow-up. SETTING: United States, multistate. PARTICIPANTS: A total of 121,700 female registered nurses who were 30 to 55 years of age in 1976; the follow-up rate was 90% as of 1988. MAIN OUTCOME MEASURE: Ovarian cancer of epithelial origin confirmed by medical record review. RESULTS: We observed a strong inverse association between tubal ligation and ovarian cancer, which persisted after adjustment for age, oral contraceptive use, parity, and other ovarian cancer risk factors (multivariate relative risk [RR], 0.33; 95% confidence interval [CI], 0.16 to 0.64). The association was similar when we assessed tubal ligation status at the baseline questionnaire and excluded cases in the first 4 years to eliminate any possible short-term decrease in risk due to screening of the ovaries during ligation surgery. We noted a weaker inverse association between simple hysterectomy and ovarian cancer (RR, 0.67; 95% CI, 0.45 to 1.00). Neither vasectomy nor condom use by a partner was associated with risk of ovarian cancer. CONCLUSIONS: These data indicate that tubal ligation, and perhaps hysterectomy, may substantially reduce risk of epithelial ovarian cancer.
OBJECTIVE: To assess whether tubal ligation and hysterectomy affect subsequent risk of ovarian cancer. DESIGN: Prospective cohort study with 12 years of follow-up. SETTING: United States, multistate. PARTICIPANTS: A total of 121,700 female registered nurses who were 30 to 55 years of age in 1976; the follow-up rate was 90% as of 1988. MAIN OUTCOME MEASURE: Ovarian cancer of epithelial origin confirmed by medical record review. RESULTS: We observed a strong inverse association between tubal ligation and ovarian cancer, which persisted after adjustment for age, oral contraceptive use, parity, and other ovarian cancer risk factors (multivariate relative risk [RR], 0.33; 95% confidence interval [CI], 0.16 to 0.64). The association was similar when we assessed tubal ligation status at the baseline questionnaire and excluded cases in the first 4 years to eliminate any possible short-term decrease in risk due to screening of the ovaries during ligation surgery. We noted a weaker inverse association between simple hysterectomy and ovarian cancer (RR, 0.67; 95% CI, 0.45 to 1.00). Neither vasectomy nor condom use by a partner was associated with risk of ovarian cancer. CONCLUSIONS: These data indicate that tubal ligation, and perhaps hysterectomy, may substantially reduce risk of epithelial ovarian cancer.
Authors: Thomas A Sellers; Yifan Huang; Julie Cunningham; Ellen L Goode; Rebecca Sutphen; Robert A Vierkant; Linda E Kelemen; Zachary S Fredericksen; Mark Liebow; V Shane Pankratz; Lynn C Hartmann; Jeff Myer; Edwin S Iversen; Joellen M Schildkraut; Catherine Phelan Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-02 Impact factor: 4.254
Authors: José Augusto Rinck-Junior; Cristiane Oliveira; Gustavo Jacob Lourenço; Regina Aparecida Martinho Sagarra; Sophie Françoise Mauricette Derchain; José Getulio Segalla; Carmen Silvia Passos Lima Journal: J Cancer Res Clin Oncol Date: 2014-08-05 Impact factor: 4.553