Literature DB >> 3026848

Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.

F Z Chung, K U Lentes, J Gocayne, M Fitzgerald, D Robinson, A R Kerlavage, C M Fraser, J C Venter.   

Abstract

Two cDNA clones, lambda-CLFV-108 and lambda-CLFV-119, encoding for the beta-adrenergic receptor, have been isolated from a human brain stem cDNA library. One human genomic clone, LCV-517 (20 kb), was characterized by restriction mapping and partial sequencing. The human brain beta-receptor consists of 413 amino acids with a calculated Mr of 46480. The gene contains three potential glucocorticoid receptor-binding sites. The beta-receptor expressed in human brain was homology with rodent (88%) and avian (52%) beta-receptors and with porcine muscarinic cholinergic receptors (31%), supporting our proposal [(1984) Proc. Natl. Acad. Sci. USA 81, 272 276] that adrenergic and muscarinic cholinergic receptors are structurally related. This represents the first cloning of a neurotransmitter receptor gene from human brain.

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Year:  1987        PMID： 3026848     DOI： 10.1016/0014-5793(87)81436-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  18 in total

Review 1.  In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors.

Authors:  T M Savarese; C M Fraser
Journal:  Biochem J       Date:  1992-04-01       Impact factor: 3.857

2.  Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.

Authors:  L J Emorine; S Marullo; C Delavier-Klutchko; S V Kaveri; O Durieu-Trautmann; A D Strosberg
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

3.  Distribution of the beta-2 adrenergic receptor messenger RNA in the rat brain by in situ hybridization histochemistry: effects of chronic reserpine treatment.

Authors:  M Asanuma; N Ogawa; K Mizukawa; K Haba; H Hirata; A Mori
Journal:  Neurochem Res       Date:  1991-12       Impact factor: 3.996

Review 4.  Molecular biology of adrenergic and dopamine receptors and the study of developmental nephrology.

Authors:  P A Jose; R A Felder; C C Felder; W Y Chan
Journal:  Pediatr Nephrol       Date:  1990-11       Impact factor: 3.714

5.  Continuous monitoring of receptor-mediated changes in the metabolic rates of living cells.

Authors:  J C Owicki; J W Parce; K M Kercso; G B Sigal; V C Muir; J C Venter; C M Fraser; H M McConnell
Journal:  Proc Natl Acad Sci U S A       Date:  1990-05       Impact factor: 11.205

Review 6.  Molecular biology and respiratory disease. 5. Molecular biology of receptors: implications for lung disease.

Authors:  P J Barnes
Journal:  Thorax       Date:  1990-06       Impact factor: 9.139

7.  Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.

Authors:  J Gocayne; D A Robinson; M G FitzGerald; F Z Chung; A R Kerlavage; K U Lentes; J Lai; C D Wang; C M Fraser; J C Venter
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205

8.  Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

Authors:  J R Hadcock; C C Malbon
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

Review 9.  Beta 2 adrenergic receptors in asthma: a current perspective.

Authors:  T R Bai
Journal:  Lung       Date:  1992       Impact factor: 2.584

10.  Changes in beta 1- and beta 2-adrenergic receptor mRNA levels in brown adipose tissue and heart of hypothyroid rats.

Authors:  J P Revelli; R Pescini; P Muzzin; J Seydoux; M G Fitzgerald; C M Fraser; J P Giacobino
Journal:  Biochem J       Date:  1991-08-01       Impact factor: 3.857
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