Surface functionalization of polytetrafluoroethylene substrate with hybrid processes comprising plasma treatment and chemical reactions.

Polytetrafluoroethylene (PTFE) exhibits excellent mechanical properties and chemical stability and has been widely used in medical fields for the preparation of implantable medical devices. However, the implantation of PTFE in living systems results in inflammation reactions and infections at the surface thus limits its long-term applications. For PTFE surface modification, we examined the effects of mussel-inspired polydopamine (PDA) coating and the further introduction of functional groups. During PDA coating, the plasma pretreatment on PTFE enhanced the stability of the PDA coating layer. Furthermore, the introduction of functional groups on the PDA layer was carried out using reactive functional groups for the photoinduced graft polymerization of methacrylate. For instance, 2-methacryloyloxyethyl phosphorylcholine (MPC) could be polymerized from the surface of the substrate. These chemical modifications were confirmed step by step using spectroscopes to obtain the hydrophilic surface of the poly(MPC)-modified PTFE. The protein adsorption behaviors on PTFE and poly(MPC)-modified PTFE were compared to understand biocompatibility characteristics of these substrates. The surface of PTFE was immediately covered with albumin and the contact between the substrate and the serum resulted in an increase in the fibrinogen composition with time. On the other hand, fewer proteins were adsorbed on the poly(MPC)-modified PTFE substrate. Thus, this modification procedure would serve as a strategy for safer alterations in PTFE surfaces to expand the life span of the PTFE-carrying medical devices in living systems.