Deniz Mut Surmeli1, Zeki Gokhan Surmeli2, Remzi Bahsi3, Tugba Turgut3, Hande Selvi Oztorun3, Volkan Atmis4, Murat Varli3, Sevgi Aras3. 1. Department of Geriatrics, Ibni-i Sina Hospital, Ankara University School of Medicine, 06230, Ankara, Turkey. denizmut19@yahoo.com. 2. Department of Medical Oncology, Ankara Medical Park Hospital, 06680, Ankara, Turkey. 3. Department of Geriatrics, Ibni-i Sina Hospital, Ankara University School of Medicine, 06230, Ankara, Turkey. 4. Department of Geriatrics, Bursa Sevket Yilmaz Training and Research Hospital, 16310, Bursa, Turkey.
Abstract
BACKGROUND: Vitamin D deficiency is known to cause increased predisposition to various infectious diseases and the addition of vitamin D to antimicrobial treatment may improve treatment responses. However, the relationship between vitamin D and Helicobacter pylori (H. pylori) remains to be determined. AIMS: To assess the association between vitamin D deficiency and H. pylori infection. METHODS: This cross-sectional study included patients aged 65 and over, who underwent gastroscopy and had gastric biopsy performed between 2010 and 2017. Of the 441 patients, 254 had available 25-hydroxyvitamin D level results and were included in the analyses. Patients were categorized into H. pylori (+) and H. pylori (-) groups, according to histopathological examination results of gastric biopsies. Serum 25(OH) vitamin D levels less than 20 ng/mL were defined as vitamin D deficiency. RESULTS: Of all patients, 43 were H. pylori (+) and 211 were H. pylori (-). More patients had vitamin D deficiency (< 20 ng/mL) in the H. pylori (+) group than the H. pylori (-) group (86% vs 67.3%, p = 0.014). The proportion of H. pylori (+) patients decreased across increasing quartiles of 25(OH) vitamin D levels (p for trend = 0.010). In multivariable logistic regression analysis, vitamin D deficiency was associated with increased odds of H. pylori infection after adjustment for age, gender, and Charlson Comorbidity Index (OR = 3.02, 95% CI 1.19-7.69, p = 0.020). CONCLUSION: Vitamin D deficiency can be associated with increased risk of H. pylori infection. The potential protective effect of vitamin D against H. pylori infection and its possible role in the treatment of H. pylori should be evaluated in prospective trials.
BACKGROUND:Vitamin D deficiency is known to cause increased predisposition to various infectious diseases and the addition of vitamin D to antimicrobial treatment may improve treatment responses. However, the relationship between vitamin D and Helicobacter pylori (H. pylori) remains to be determined. AIMS: To assess the association between vitamin Ddeficiency and H. pylori infection. METHODS: This cross-sectional study included patients aged 65 and over, who underwent gastroscopy and had gastric biopsy performed between 2010 and 2017. Of the 441 patients, 254 had available 25-hydroxyvitamin D level results and were included in the analyses. Patients were categorized into H. pylori (+) and H. pylori (-) groups, according to histopathological examination results of gastric biopsies. Serum 25(OH) vitamin D levels less than 20 ng/mL were defined as vitamin D deficiency. RESULTS: Of all patients, 43 were H. pylori (+) and 211 were H. pylori (-). More patients had vitamin D deficiency (< 20 ng/mL) in the H. pylori (+) group than the H. pylori (-) group (86% vs 67.3%, p = 0.014). The proportion of H. pylori (+) patients decreased across increasing quartiles of 25(OH) vitamin D levels (p for trend = 0.010). In multivariable logistic regression analysis, vitamin D deficiency was associated with increased odds of H. pyloriinfection after adjustment for age, gender, and Charlson Comorbidity Index (OR = 3.02, 95% CI 1.19-7.69, p = 0.020). CONCLUSION:Vitamin D deficiency can be associated with increased risk of H. pyloriinfection. The potential protective effect of vitamin D against H. pyloriinfection and its possible role in the treatment of H. pylori should be evaluated in prospective trials.
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Keywords:
25-Hydroxyvitamin D 2; Aged; Gastroscopy; Helicobacter pylori; Vitamin D deficiency