Asher Shafrir1,2, Michal Shauly-Aharonov3,4, Lior H Katz2, Ora Paltiel4,5, Yishai Pickman6, Zvi Ackerman7. 1. Division of Medicine, Meuhedet Health Services, Tel Aviv 6203854, Israel. 2. Hadassah Medical Center, The Department of Gastroenterology, Faculty of Medicine, Ein Karem Campus, Hebrew University of Jerusalem, P.O. Box 12249, Jerusalem 9112102, Israel. 3. The Jerusalem College of Technology, P.O. Box 16031, Jerusalem 91160, Israel. 4. Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel. 5. Hadassah Medical Center, Department of Hematology, Faculty of Medicine, Ein Karem Campus, Hebrew University of Jerusalem, Jerusalem 9112102, Israel. 6. K-Health Inc., Tel Aviv 6581706, Israel. 7. Hadassah Medical Center, Department of Medicine, Faculty of Medicine, Mount Scopus Campus, Hebrew University of Jerusalem, P.O. Box 24035, Jerusalem 91240, Israel.
Abstract
BACKGROUND: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, using a large electronic database based on medical records from a population-based health maintenance organization. METHODS: Data regarding adults who underwent H. pylori testing and had vitamin D measurements within one month of H. pylori testing were collected. H. pylori infection was ascertained using urea breath or stool antigen tests. A negative H. pylori test following a positive result implied eradication. Multivariate regression models were constructed to assess associations between H. pylori infection, eradication, and vitamin D. RESULTS: Among 150,483 members who underwent H. pylori testing from 2009 to 2018, 27,077 (18%) had vitamin D measurements. Vitamin D levels were inversely associated with H. pylori infection, p < 0.001. The odds of a positive H. pylori test were 31% higher among patients with vitamin D levels <20 ng/mL, compared with those with levels ≥20 ng/mL (OR 1.31, 99% CI 1.22-1.4, p < 0.001). Purchase of vitamin D supplements was associated with a negative subsequent H. pylori test (p < 0.001). Mean vitamin D levels were moderately higher in those with successful vs. failed H. pylori eradication (19.34 ± 9.55 vs. 18.64 ± 9.61, p < 0.001). CONCLUSIONS: Vitamin D levels are associated with H. pylori infection. Increased vitamin D levels are associated with successful H. pylori eradication. Vitamin D may have a role in H. pylori eradication.
BACKGROUND: The success of Helicobacter pylori (H. pylori) eradication depends on several host and treatment factors. Serum vitamin D levels may be associated with H. pylori infection and eradication rates. We investigated the association between vitamin D and H. pylori infection and eradication, using a large electronic database based on medical records from a population-based health maintenance organization. METHODS: Data regarding adults who underwent H. pylori testing and had vitamin D measurements within one month of H. pylori testing were collected. H. pylori infection was ascertained using urea breath or stool antigen tests. A negative H. pylori test following a positive result implied eradication. Multivariate regression models were constructed to assess associations between H. pylori infection, eradication, and vitamin D. RESULTS: Among 150,483 members who underwent H. pylori testing from 2009 to 2018, 27,077 (18%) had vitamin D measurements. Vitamin D levels were inversely associated with H. pylori infection, p < 0.001. The odds of a positive H. pylori test were 31% higher among patients with vitamin D levels <20 ng/mL, compared with those with levels ≥20 ng/mL (OR 1.31, 99% CI 1.22-1.4, p < 0.001). Purchase of vitamin D supplements was associated with a negative subsequent H. pylori test (p < 0.001). Mean vitamin D levels were moderately higher in those with successful vs. failed H. pylori eradication (19.34 ± 9.55 vs. 18.64 ± 9.61, p < 0.001). CONCLUSIONS:Vitamin D levels are associated with H. pylori infection. Increased vitamin D levels are associated with successful H. pylori eradication. Vitamin D may have a role in H. pylori eradication.
Authors: Lin Zhang; William K K Wu; Richard L Gallo; Evandro F Fang; Wei Hu; Thomas K W Ling; Jing Shen; Ruby L Y Chan; Lan Lu; Xiao M Luo; Ming X Li; Kam M Chan; Jun Yu; Vincent W S Wong; Siew C Ng; Sunny H Wong; Francis K L Chan; Joseph J Y Sung; Matthew T V Chan; Chi H Cho Journal: J Immunol Date: 2016-01-22 Impact factor: 5.422