Stephan Müller1, Oliver Preische2, Hamid R Sohrabi3, Susanne Gräber4, Mathias Jucker5, John M Ringman6, Ralph N Martins3, Eric McDade7, Peter R Schofield8, Bernardino Ghetti9, Martin Rossor10, Nick N Fox10, Neill R Graff-Radford11, Johannes Levin12, Adrian Danek12, Jonathan Vöglein12, Stephen Salloway13, Chengjie Xiong14, Tammie Benzinger15, Virginia Buckles15, Colin L Masters16, Reisa Sperling17, Randall J Bateman15, John C Morris15, Christoph Laske4. 1. Section for Dementia Research, Department of Cellular Neurology, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany. Electronic address: stephan.mueller@med.uni-tuebingen.de. 2. Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. 3. Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; Department of Biomedical Sciences, Macquarie University, Sydney, NSW, Australia. 4. Section for Dementia Research, Department of Cellular Neurology, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. 5. German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany; Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. 6. Memory and Aging Center, Keck School of Medicine of USC, Los Angeles, CA, USA. 7. University of Pittsburgh School of Medicine, Department of Neurology, Pittsburgh, PA, USA. 8. Neuroscience Research Australia, Randwick, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia. 9. Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA. 10. Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, Queen Square, London, UK. 11. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA. 12. German Center for Neurodegenerative Diseases (DZNE), München, Germany; Department of Neurology, Ludwig-Maximilians University Munich, Munich, Germany. 13. Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, USA. 14. Division of Biostatistics, The Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St Louis, MO, USA. 15. Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. 16. The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia. 17. Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Abstract
INTRODUCTION: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). METHODS: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. RESULTS: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. DISCUSSION: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.
INTRODUCTION: Little is known about effects of physical activity (PA) in genetically driven early-onset autosomal dominant Alzheimer's disease (AD). METHODS: A total of 372 individuals participating at the Dominantly Inherited Alzheimer Network study were examined to evaluate the cross-sectional relationship of PA with cognitive performance, functional status, cognitive decline, and AD biomarkers in cerebrospinal fluid. Mutation carriers were categorized as high or low exercisers according to WHO recommendations. RESULTS: Mutation carriers with high PA showed significantly better cognitive and functional performance and significantly less AD-like pathology in cerebrospinal fluid than individuals with low PA. Mutation carriers with high PA scored 3.4 points better on Mini Mental State Examination at expected symptom onset and fulfilled the diagnosis of very mild dementia 15.1 years later compared with low exercisers. DISCUSSION: These results support a beneficial effect of PA on cognition and AD pathology even in individuals with genetically driven autosomal dominant AD.
Authors: Sid E O'Bryant; Stephen C Waring; C Munro Cullum; James Hall; Laura Lacritz; Paul J Massman; Philip J Lupo; Joan S Reisch; Rachelle Doody Journal: Arch Neurol Date: 2008-08
Authors: Belinda M Brown; Hamid R Sohrabi; Kevin Taddei; Samantha L Gardener; Stephanie R Rainey-Smith; Jeremiah J Peiffer; Chengjie Xiong; Anne M Fagan; Tammie Benzinger; Virginia Buckles; Kirk I Erickson; Roger Clarnette; Tejal Shah; Colin L Masters; Michael Weiner; Nigel Cairns; Martin Rossor; Neill R Graff-Radford; Stephen Salloway; Jonathan Vöglein; Christoph Laske; James Noble; Peter R Schofield; Randall J Bateman; John C Morris; Ralph N Martins Journal: Alzheimers Dement Date: 2017-05-11 Impact factor: 21.566
Authors: Stefano Brini; Hamid R Sohrabi; Jeremiah J Peiffer; Mira Karrasch; Heikki Hämäläinen; Ralph N Martins; Timothy J Fairchild Journal: Sports Med Date: 2018-01 Impact factor: 11.136
Authors: Ronald C Petersen; Oscar Lopez; Melissa J Armstrong; Thomas S D Getchius; Mary Ganguli; David Gloss; Gary S Gronseth; Daniel Marson; Tamara Pringsheim; Gregory S Day; Mark Sager; James Stevens; Alexander Rae-Grant Journal: Neurology Date: 2017-12-27 Impact factor: 9.910
Authors: Ozioma C Okonkwo; Stephanie A Schultz; Jennifer M Oh; Jordan Larson; Dorothy Edwards; Dane Cook; Rebecca Koscik; Catherine L Gallagher; N M Dowling; Cynthia M Carlsson; Barbara B Bendlin; Asenath LaRue; Howard A Rowley; Brad T Christian; Sanjay Asthana; Bruce P Hermann; Sterling C Johnson; Mark A Sager Journal: Neurology Date: 2014-10-08 Impact factor: 9.910
Authors: Robert D Abbott; Lon R White; G Webster Ross; Kamal H Masaki; J David Curb; Helen Petrovitch Journal: JAMA Date: 2004-09-22 Impact factor: 56.272
Authors: Yonas E Geda; Rosebud O Roberts; David S Knopman; Teresa J H Christianson; V Shane Pankratz; Robert J Ivnik; Bradley F Boeve; Eric G Tangalos; Ronald C Petersen; Walter A Rocca Journal: Arch Neurol Date: 2010-01
Authors: Kathryn E Nichol; Wayne W Poon; Anna I Parachikova; David H Cribbs; Charles G Glabe; Carl W Cotman Journal: J Neuroinflammation Date: 2008-04-09 Impact factor: 8.322
Authors: Kaitlin B Casaletto; Miguel Arce Rentería; Judy Pa; Sarah E Tom; Amal Harrati; Nicole M Armstrong; K Bharat Rajan; Dan Mungas; Samantha Walters; Joel Kramer; Laura B Zahodne Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472
Authors: K B Casaletto; A M Staffaroni; A Wolf; B Appleby; D Brushaber; G Coppola; B Dickerson; K Domoto-Reilly; F M Elahi; J Fields; J C Fong; L Forsberg; N Ghoshal; N Graff-Radford; M Grossman; H W Heuer; G-Y Hsiung; E D Huey; D Irwin; K Kantarci; D Kaufer; D Kerwin; D Knopman; J Kornak; J H Kramer; I Litvan; I R Mackenzie; M Mendez; B Miller; R Rademakers; E M Ramos; K Rascovsky; E D Roberson; J A Syrjanen; M C Tartaglia; S Weintraub; B Boeve; A L Boxer; H Rosen; K Yaffe Journal: Alzheimers Dement Date: 2020-01 Impact factor: 21.566
Authors: Giovanni B Frisoni; Daniele Altomare; Dietmar Rudolf Thal; Federica Ribaldi; Rik van der Kant; Rik Ossenkoppele; Kaj Blennow; Jeffrey Cummings; Cornelia van Duijn; Peter M Nilsson; Pierre-Yves Dietrich; Philip Scheltens; Bruno Dubois Journal: Nat Rev Neurosci Date: 2021-11-23 Impact factor: 34.870
Authors: Kaitlin B Casaletto; Cutter A Lindbergh; Anna VandeBunte; John Neuhaus; Julie A Schneider; Aron S Buchman; William G Honer; David A Bennett Journal: J Neurosci Date: 2021-11-22 Impact factor: 6.709
Authors: Julie Gonneaud; Christophe Bedetti; Alexa Pichet Binette; Tammie L S Benzinger; John C Morris; Randall J Bateman; Judes Poirier; John C S Breitner; Sylvia Villeneuve Journal: Neurology Date: 2020-08-05 Impact factor: 9.910