Literature DB >> 30264077

Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).

Emanuele Rossini1, Jan Gajewski, Maja Klaus, Gerhard Hummer, Martin Grininger.   

Abstract

Perturbations of domain-domain interactions impact the function of type I fatty acid synthases. We identify interface point mutations that modulate fatty acid chain lengths, and explain their effect in changes of domain-domain binding energetics. Engineering of similar interfaces in related megasynthases may be exploited for custom synthesis of natural products.

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Year:  2018        PMID： 30264077     DOI： 10.1039/c8cc06838k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Molecular basis for interactions between an acyl carrier protein and a ketosynthase.

Authors:  Jacob C Milligan; D John Lee; David R Jackson; Andrew J Schaub; Joris Beld; Jesus F Barajas; Joseph J Hale; Ray Luo; Michael D Burkart; Shiou-Chuan Tsai
Journal:  Nat Chem Biol       Date:  2019-06-17       Impact factor: 15.040

2.  Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases.

Authors:  Jeffrey T Mindrebo; Aochiu Chen; Woojoo E Kim; Rebecca N Re; Tony D Davis; Joseph P Noel; Michael D Burkart
Journal:  ACS Catal       Date:  2021-05-26       Impact factor: 13.700

3.  Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD.

Authors:  Laetitia E Misson; Jeffrey T Mindrebo; Tony D Davis; Ashay Patel; J Andrew McCammon; Joseph P Noel; Michael D Burkart
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-14       Impact factor: 11.205

4.  Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains.

Authors:  Maja Klaus; Alicia D D'Souza; Aleksandra Nivina; Chaitan Khosla; Martin Grininger
Journal:  ACS Chem Biol       Date:  2019-02-11       Impact factor: 5.100

5.  Type I fatty acid synthase trapped in the octanoyl-bound state.

Authors:  Alexander Rittner; Karthik S Paithankar; Aaron Himmler; Martin Grininger
Journal:  Protein Sci       Date:  2020-02       Impact factor: 6.725

6.  Solution Structure and Conformational Flexibility of a Polyketide Synthase Module.

Authors:  Maja Klaus; Emanuele Rossini; Andreas Linden; Karthik S Paithankar; Matthias Zeug; Zoya Ignatova; Henning Urlaub; Chaitan Khosla; Jürgen Köfinger; Gerhard Hummer; Martin Grininger
Journal:  JACS Au       Date:  2021-10-18

Review 7.  Enzymology of standalone elongating ketosynthases.

Authors:  Aochiu Chen; Ziran Jiang; Michael D Burkart
Journal:  Chem Sci       Date:  2022-03-09       Impact factor: 9.825
  7 in total

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