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Literature DB >> 30263935

Regulation of protein metabolism in cancer.

Cecil Han¹, Xiongbin Lu¹, Deepak Nagrath².

Abstract

Our recent studies determined molecular interactions between genes in the ubiquitin-proteasome pathways and cancer cell metabolism. Ubiquitin-specific peptidase 13 (USP13) specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase that drive ovarian cancer metabolism. These findings may lead to the development of USP13 inhibitors and new-targeted therapies in ovarian cancers.

Entities: Disease Gene

Keywords: ACLY; OGDH; USP13; cancer genomics; cancer metabolism; ovarian cancer

Year: 2018 PMID： 30263935 PMCID： PMC6154860 DOI： 10.1080/23723556.2017.1285384

Source DB: PubMed Journal: Mol Cell Oncol ISSN： 2372-3556

10 in total

1. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Authors: Andrew R Mullen; Zeping Hu; Xiaolei Shi; Lei Jiang; Lindsey K Boroughs; Zoltan Kovacs; Richard Boriack; Dinesh Rakheja; Lucas B Sullivan; W Marston Linehan; Navdeep S Chandel; Ralph J DeBerardinis
Journal: Cell Rep Date: 2014-05-22 Impact factor: 9.423

Review 2. Proteasome deubiquitinases as novel targets for cancer therapy.

Authors: Pádraig D'Arcy; Stig Linder
Journal: Int J Biochem Cell Biol Date: 2012-07-20 Impact factor: 5.085

3. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth.

Authors: Lifeng Yang; Abhinav Achreja; Tsz-Lun Yeung; Lingegowda S Mangala; Dahai Jiang; Cecil Han; Joelle Baddour; Juan C Marini; Joseph Ni; Ryuichi Nakahara; Stephen Wahlig; Lisa Chiba; Sun Hye Kim; Joshua Morse; Sunila Pradeep; Archana Sidalaghatta Nagaraja; Monika Haemmerle; Noh Kyunghee; Mathew Derichsweiler; Thomas Plackemeier; Imelda Mercado-Uribe; Gabriel Lopez-Berestein; Tyler Moss; Prahlad T Ram; Jinsong Liu; Xiongbin Lu; Samuel C Mok; Anil K Sood; Deepak Nagrath
Journal: Cell Metab Date: 2016-11-08 Impact factor: 27.287

Review 4. Targeting cancer metabolism: a therapeutic window opens.

Authors: Matthew G Vander Heiden
Journal: Nat Rev Drug Discov Date: 2011-08-31 Impact factor: 84.694

Review 5. ATP-citrate lyase: a mini-review.

Authors: Melanie Chypre; Nousheen Zaidi; Karine Smans
Journal: Biochem Biophys Res Commun Date: 2012-05-03 Impact factor: 3.575

Review 6. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.

Authors: David D Bowtell; Steffen Böhm; Ahmed A Ahmed; Paul-Joseph Aspuria; Robert C Bast; Valerie Beral; Jonathan S Berek; Michael J Birrer; Sarah Blagden; Michael A Bookman; James D Brenton; Katherine B Chiappinelli; Filipe Correia Martins; George Coukos; Ronny Drapkin; Richard Edmondson; Christina Fotopoulou; Hani Gabra; Jérôme Galon; Charlie Gourley; Valerie Heong; David G Huntsman; Marcin Iwanicki; Beth Y Karlan; Allyson Kaye; Ernst Lengyel; Douglas A Levine; Karen H Lu; Iain A McNeish; Usha Menon; Steven A Narod; Brad H Nelson; Kenneth P Nephew; Paul Pharoah; Daniel J Powell; Pilar Ramos; Iris L Romero; Clare L Scott; Anil K Sood; Euan A Stronach; Frances R Balkwill
Journal: Nat Rev Cancer Date: 2015-11 Impact factor: 60.716

7. Whole-genome characterization of chemoresistant ovarian cancer.

Authors: Ann-Marie Patch; Elizabeth L Christie; Dariush Etemadmoghadam; Dale W Garsed; Joshy George; Sian Fereday; Katia Nones; Prue Cowin; Kathryn Alsop; Peter J Bailey; Karin S Kassahn; Felicity Newell; Michael C J Quinn; Stephen Kazakoff; Kelly Quek; Charlotte Wilhelm-Benartzi; Ed Curry; Huei San Leong; Anne Hamilton; Linda Mileshkin; George Au-Yeung; Catherine Kennedy; Jillian Hung; Yoke-Eng Chiew; Paul Harnett; Michael Friedlander; Michael Quinn; Jan Pyman; Stephen Cordner; Patricia O'Brien; Jodie Leditschke; Greg Young; Kate Strachan; Paul Waring; Walid Azar; Chris Mitchell; Nadia Traficante; Joy Hendley; Heather Thorne; Mark Shackleton; David K Miller; Gisela Mir Arnau; Richard W Tothill; Timothy P Holloway; Timothy Semple; Ivon Harliwong; Craig Nourse; Ehsan Nourbakhsh; Suzanne Manning; Senel Idrisoglu; Timothy J C Bruxner; Angelika N Christ; Barsha Poudel; Oliver Holmes; Matthew Anderson; Conrad Leonard; Andrew Lonie; Nathan Hall; Scott Wood; Darrin F Taylor; Qinying Xu; J Lynn Fink; Nick Waddell; Ronny Drapkin; Euan Stronach; Hani Gabra; Robert Brown; Andrea Jewell; Shivashankar H Nagaraj; Emma Markham; Peter J Wilson; Jason Ellul; Orla McNally; Maria A Doyle; Ravikiran Vedururu; Collin Stewart; Ernst Lengyel; John V Pearson; Nicola Waddell; Anna deFazio; Sean M Grimmond; David D L Bowtell
Journal: Nature Date: 2015-05-28 Impact factor: 49.962

8. Mitochondria as biosynthetic factories for cancer proliferation.

Authors: Christopher S Ahn; Christian M Metallo
Journal: Cancer Metab Date: 2015-01-25

9. Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.

Authors: Lifeng Yang; Tyler Moss; Lingegowda S Mangala; Juan Marini; Hongyun Zhao; Stephen Wahlig; Guillermo Armaiz-Pena; Dahai Jiang; Abhinav Achreja; Julia Win; Rajesha Roopaimoole; Cristian Rodriguez-Aguayo; Imelda Mercado-Uribe; Gabriel Lopez-Berestein; Jinsong Liu; Takashi Tsukamoto; Anil K Sood; Prahlad T Ram; Deepak Nagrath
Journal: Mol Syst Biol Date: 2014-05-05 Impact factor: 11.429

10. Amplification of USP13 drives ovarian cancer metabolism.

Authors: Cecil Han; Lifeng Yang; Hyun Ho Choi; Joelle Baddour; Abhinav Achreja; Yunhua Liu; Yujing Li; Jiada Li; Guohui Wan; Cheng Huang; Guang Ji; Xinna Zhang; Deepak Nagrath; Xiongbin Lu
Journal: Nat Commun Date: 2016-11-28 Impact factor: 14.919