Literature DB >> 30263706

The potential neuritogenic activity of aqueous extracts from Morchella importuna in rat pheochromocytoma cells.

Chuan Xiong1, Qiang Luo2, Wen-Li Huang1, Qiang Li1, Cheng Chen3, Zu-Qin Chen1, Zhi-Rong Yang4.   

Abstract

The aim of this study was to explore the neuritogenic effects of aqueous extracts from the fruiting bodies of Morchella importuna (MEA). 3-(4, 5-dimethythiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay was carried out to assess the cytotoxicity of MEA. Neurite outgrowth stimulation assay was used to evaluate the potentiation of neuritogenic activity induced by MEA. The specific inhibitors for TrkA, MEK/ERK and PI3K signaling pathway were served to clarify the mechanism of MEA's neuritogenic effects. It was shown that MEA could mimic neuritogenic activity of NGF, a kind of representative neurotrophic factors with no significant cytotoxicity, and stimulate neurite outgrowth in a dose-dependent manner of PC12 cells. The neuritogenic activity induced by MEA required activity of PI3K/Akt and MEK/ERK1/2 signaling pathways, as well as parts of TrkA receptor. Accordingly, MEA could be used as a promising neuritogenic-stimulation compound for nervous diseases treatment.

Entities:  

Keywords:  Culinary-medicinal mushroom; Morchella importuna; Nerve growth factor; Neuritogenic effect; Neurodegenerative disease

Year:  2017        PMID： 30263706      PMCID： PMC6049703          DOI： 10.1007/s10068-017-0224-x

Source DB:  PubMed          Journal:  Food Sci Biotechnol        ISSN： 1226-7708            Impact factor:   2.391


  30 in total

1.  Hepatoprotective activity of cultured mycelium of Morel mushroom, Morchella esculenta.

Authors:  B Nitha; P V Fijesh; K K Janardhanan
Journal:  Exp Toxicol Pathol       Date:  2011-07-12

2.  Purification, antitumor and immunomodulatory activity of polysaccharides from soybean residue fermented with Morchella esculenta.

Authors:  Shuhong Li; Ang Gao; Shuang Dong; Ye Chen; Shuang Sun; Zhongfang Lei; Zhenya Zhang
Journal:  Int J Biol Macromol       Date:  2016-12-08       Impact factor: 6.953

3.  Preclinical toxicological evaluations of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk mushroom.

Authors:  Sook Shien Lee; Francis Kanyan Enchang; Nget Hong Tan; Shin Yee Fung; Jayalakshmi Pailoor
Journal:  J Ethnopharmacol       Date:  2013-02-28       Impact factor: 4.360

4.  Neuroprotective effect of crude polysaccharide isolated from the fruiting bodies of Morchella importuna against H2O2-induced PC12 cell cytotoxicity by reducing oxidative stress.

Authors:  Chuan Xiong; Qiang Li; Cheng Chen; Zuqin Chen; Wenli Huang
Journal:  Biomed Pharmacother       Date:  2016-07-25       Impact factor: 6.529

5.  Aqueous-ethanolic extract of morel mushroom mycelium Morchella esculenta, protects cisplatin and gentamicin induced nephrotoxicity in mice.

Authors:  B Nitha; K K Janardhanan
Journal:  Food Chem Toxicol       Date:  2008-07-22       Impact factor: 6.023

6.  Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways.

Authors:  Chia-Wei Phan; Guan-Serm Lee; Sok-Lai Hong; Yuin-Teng Wong; Robert Brkljača; Sylvia Urban; Sri Nurestri Abd Malek; Vikineswary Sabaratnam
Journal:  Food Funct       Date:  2014-12       Impact factor: 5.396

7.  Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis.

Authors:  Z Xia; M Dickens; J Raingeaud; R J Davis; M E Greenberg
Journal:  Science       Date:  1995-11-24       Impact factor: 47.728

8.  Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.

Authors:  Syntyche Ling-Sing Seow; Murali Naidu; Pamela David; Kah-Hui Wong; Vikineswary Sabaratnam
Journal:  BMC Complement Altern Med       Date:  2013-07-04       Impact factor: 3.659

9.  Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.

Authors:  Chia-Wei Phan; Pamela David; Murali Naidu; Kah-Hui Wong; Vikineswary Sabaratnam
Journal:  BMC Complement Altern Med       Date:  2013-10-11       Impact factor: 3.659

10.  Neuritogenic monoglyceride derived from the constituent of a marine fish for activating the PI3K/ERK/CREB signalling pathways in PC12 cells.

Authors:  Wei Yang; Yan Luo; Ruiqi Tang; Hui Zhang; Ying Ye; Lan Xiang; Jianhua Qi
Journal:  Int J Mol Sci       Date:  2013-12-12       Impact factor: 5.923
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  3 in total

Review 1.  A comprehensive review on Morchella importuna: cultivation aspects, phytochemistry, and other significant applications.

Authors:  Krishika Sambyal; Rahul Vikram Singh
Journal:  Folia Microbiol (Praha)       Date:  2021-01-19       Impact factor: 2.099

2.  Total phenolics, antioxidant activities and fatty acid profiles of six Morchella species.

Authors:  Hatıra Taşkın; Özge Süfer; Şule Hilal Attar; Fuat Bozok; Gökhan Baktemur; Saadet Büyükalaca; Nesibe Ebru Kafkas
Journal:  J Food Sci Technol       Date:  2020-06-22       Impact factor: 2.701

3.  The whole-genome sequence analysis of Morchella sextelata.

Authors: 
Journal:  Sci Rep       Date:  2019-10-25       Impact factor: 4.379
  3 in total

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