Computational analysis of linear energy modulation for laser thermal coagulation.

Accurate treatment planning and monitoring are critical factors to ensure safe and effective outcomes of laser thermal coagulation (LTC). Computational and experimental models based upon linear energy modulation were deployed to predict temperature distribution and thermal damage within ex vivo porcine liver. 1470-nm Gaussian emission was confirmed by using digital imaging and the customized goniometry. The tissue temperature was maintained in the pre-determined range (65~75 °C) to induce thermally destructive volumes of 0.23 cm3 (simulation) and 0.17 ± 0.05 cm3 (experiment) once the applied power was linearly reduced from 3.5 W to 0.2 W in 50 s ("3.5 W fast slope" laser modulation mode). The proposed model may be a useful tool to predict thermal responses of the tissue during LTC.