Stephanie Glass Clark1, Anna S Nagle2, Rachel Bernardo3, Naomi Vinod4, Laura Carucci5, Ashley Carroll6, John Speich2, Adam P Klausner7. 1. From the Department of Obstetrics and Gynecology, Virginia Commonwealth University Health System. 2. Department of Mechanical and Nuclear Engineering. 3. Department of Biomedical Engineering. 4. Department of Anatomy and Neurobiology, Virginia Commonwealth University. 5. Department of Radiology. 6. Female Pelvic Medicine and Reconstructive Surgery Division, Department of Obstetrics and Gynecology. 7. Division of Urology, Department of Surgery, Virginia Commonwealth University Health System, Richmond, VA.
Abstract
OBJECTIVES: The objective of this study was to identify differences in bladder shape changes between individuals with overactive bladder (OAB) and unaffected individuals during ultrasound urodynamics. METHODS: A prospective urodynamic study was performed with concurrent transabdominal ultrasound (ultrasound urodynamics) on individuals with and without OAB based on validated International Consultation on Incontinence Questionnaire - OAB survey scores. Three-dimensional ultrasound images were acquired at 1-minute increments during filling and used to measure bladder diameters in the height, width, and depth orientations. The engineering strain for each diameter was compared between participants with OAB and controls during urodynamic filling. The height-to-width ratio at capacity was used to determine if individuals were shape outliers. RESULTS: A total of 22 subjects were enrolled, including 11 with OAB and 11 without OAB. During urodynamic filling in both groups, the greatest degree of geometric strain was found in the height orientation, indicating that bladders generally fill in a craniocaudal shape. The mean ± SD height-to-width ratio of the control group was 1.06 ± 0.12 yielding a 95% confidence interval of 0.82 to 1.30. Five (45.5%) of 11 OAB subjects had height-to-width ratios outside this interval as compared with none of the control subjects, identifying a potential shape-mediated subgroup of OAB. CONCLUSIONS: Three-dimensional ultrasound urodynamics can be used to identify differences in bladder shape comparing individuals with and without OAB. This method may be used to identify a subset of OAB patients with abnormal bladder shapes which may play a role in the pathophysiology of their OAB symptoms.
OBJECTIVES: The objective of this study was to identify differences in bladder shape changes between individuals with overactive bladder (OAB) and unaffected individuals during ultrasound urodynamics. METHODS: A prospective urodynamic study was performed with concurrent transabdominal ultrasound (ultrasound urodynamics) on individuals with and without OAB based on validated International Consultation on Incontinence Questionnaire - OAB survey scores. Three-dimensional ultrasound images were acquired at 1-minute increments during filling and used to measure bladder diameters in the height, width, and depth orientations. The engineering strain for each diameter was compared between participants with OAB and controls during urodynamic filling. The height-to-width ratio at capacity was used to determine if individuals were shape outliers. RESULTS: A total of 22 subjects were enrolled, including 11 with OAB and 11 without OAB. During urodynamic filling in both groups, the greatest degree of geometric strain was found in the height orientation, indicating that bladders generally fill in a craniocaudal shape. The mean ± SD height-to-width ratio of the control group was 1.06 ± 0.12 yielding a 95% confidence interval of 0.82 to 1.30. Five (45.5%) of 11 OAB subjects had height-to-width ratios outside this interval as compared with none of the control subjects, identifying a potential shape-mediated subgroup of OAB. CONCLUSIONS: Three-dimensional ultrasound urodynamics can be used to identify differences in bladder shape comparing individuals with and without OAB. This method may be used to identify a subset of OABpatients with abnormal bladder shapes which may play a role in the pathophysiology of their OAB symptoms.
Authors: Naomi N Vinod; Anna S Nagle; Hameeda A Naimi; Hiren Kolli; Derek Sheen; Naveen Nandanan; Laura R Carucci; John E Speich; Adam P Klausner Journal: Can J Urol Date: 2019-08 Impact factor: 1.344
Authors: Derek Sheen; Hiren Kolli; Anna S Nagle; Zachary Cullingsworth; Naomi N Vinod; Hameeda A Naimi; Stefan G De Wachter; Suzanne E Mazzeo; Lynn Stothers; John E Speich; Adam P Klausner Journal: Low Urin Tract Symptoms Date: 2019-07-12 Impact factor: 1.592
Authors: Rui Li; Anna S Nagle; Kaitlyn M Maddra; Naomi Vinod; Suzanne A Prince; Sarah I Tensen; Devina Thapa; Blessan Sebastian; Dhruv Sethi; Abraham Alattar; Laura R Carucci; Adam P Klausner; John E Speich Journal: Am J Clin Exp Urol Date: 2021-10-15