Elias Iosifidis1, Georgia Pitsava1, Emmanuel Roilides1. 1. Infectious Disease Unit, 3rd Department of Pediatrics, Medical Faculty, Aristotle University School of Health Sciences, Hippokration General Hospital, Thessaloniki Greece.
Abstract
AIM: While ventilator-associated pneumonia (VAP) remains frequent in Pediatric ICU, there is no gold standard for diagnosis. METHODOLOGY: We conducted a systematic PUBMED analysis (January 1990-January 2017) searching original, full-length studies addressing only pediatric patients; for VAP diagnosis, only those comparing different diagnostic methods and for VAP prevention those implementing preventive measures. RESULTS: Among 367 articles, 17 and 16 were analyzed for diagnosis and prevention, respectively. For diagnosis, 13 studies used CDC criteria; whereas, 14 assessed algorithms: clinical pulmonary index score, ventilator-associated events and biomarkers. Among five randomized trials assessing preventive strategies one found a role of probiotics. Ventilator-care bundles reduced VAP rates. CONCLUSION: Absence of diagnostic gold standard impedes comparison of current approaches and preventive strategies.
AIM: While ventilator-associated pneumonia (VAP) remains frequent in Pediatric ICU, there is no gold standard for diagnosis. METHODOLOGY: We conducted a systematic PUBMED analysis (January 1990-January 2017) searching original, full-length studies addressing only pediatric patients; for VAP diagnosis, only those comparing different diagnostic methods and for VAP prevention those implementing preventive measures. RESULTS: Among 367 articles, 17 and 16 were analyzed for diagnosis and prevention, respectively. For diagnosis, 13 studies used CDC criteria; whereas, 14 assessed algorithms: clinical pulmonary index score, ventilator-associated events and biomarkers. Among five randomized trials assessing preventive strategies one found a role of probiotics. Ventilator-care bundles reduced VAP rates. CONCLUSION: Absence of diagnostic gold standard impedes comparison of current approaches and preventive strategies.
Authors: Hugo Teixeira; Alberto Freitas; António Sarmento; Paulo Nossa; Hernâni Gonçalves; Maria de Fátima Pina Journal: Int J Environ Res Public Health Date: 2021-04-28 Impact factor: 3.390
Authors: Alejandro Pinilla-Gonzalez; Inmaculada Lara-Cantón; Laura Torrejón-Rodríguez; Anna Parra-Llorca; Marta Aguar; Julia Kuligowski; José David Piñeiro-Ramos; Ángel Sánchez-Illana; Ana Gimeno Navarro; Máximo Vento; María Cernada Journal: Pediatr Res Date: 2022-09-07 Impact factor: 3.953