Literature DB >> 30251916

Injectable Chitosan Hydrogels with Enhanced Mechanical Properties for Nucleus Pulposus Regeneration.

Yasaman Alinejad1,2,3, Atma Adoungotchodo1,2,3, Michael P Grant3, Laura M Epure3, John Antoniou3,4, Fackson Mwale3,4, Sophie Lerouge1,2.   

Abstract

IMPACT STATEMENT: A thermosensitive chitosan-based hydrogel was developed, which mimics the mechanical properties of the human nucleus pulposus (NP) tissue and provides a suitable environment for seeded NP cells to live and produce glycosaminoglycans. This scaffold is injectable through 25G needle and rapidly gels in vivo at body temperature. It has the potential to restore mechanical properties and stimulate biological repair of the degenerated intervertebral disc (IVD). It could therefore be used for the minimally invasive treatment of degenerated IVD, which affects more than one person out of five in the world.

Entities:  

Keywords:  chitosan; hydrogel; intervertebral disc; mechanical properties; nucleus pulposus

Mesh：

Substances：

Year:  2018        PMID： 30251916     DOI： 10.1089/ten.TEA.2018.0170

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  8 in total

Review 1.  Proper animal experimental designs for preclinical research of biomaterials for intervertebral disc regeneration.

Authors:  Yizhong Peng; Xiangcheng Qing; Hongyang Shu; Shuo Tian; Wenbo Yang; Songfeng Chen; Hui Lin; Xiao Lv; Lei Zhao; Xi Chen; Feifei Pu; Donghua Huang; Xu Cao; Zengwu Shao
Journal:  Biomater Transl       Date:  2021-06-28

2.  The Thermosensitive Injectable Celecoxib-Loaded Chitosan Hydrogel for Repairing Postoperative Intervertebral Disc Defect.

Authors:  Yukun Du; Jianyi Li; Xiaojie Tang; Yingying Liu; Guoshuai Bian; Jianzhuang Shi; Yixin Zhang; Baomeng Zhao; Hongri Zhao; Kunyan Sui; Yongming Xi
Journal:  Front Bioeng Biotechnol       Date:  2022-06-28

Review 3.  Advances of Naturally Derived and Synthetic Hydrogels for Intervertebral Disk Regeneration.

Authors:  Guoke Tang; Bingyan Zhou; Feng Li; Weiheng Wang; Yi Liu; Xing Wang; Chao Liu; Xiaojian Ye
Journal:  Front Bioeng Biotechnol       Date:  2020-06-30

4.  Architecture-Promoted Biomechanical Performance-Tuning of Tissue-Engineered Constructs for Biological Intervertebral Disc Replacement.

Authors:  Gernot Lang; Katja Obri; Babak Saravi; Aldo R Boccaccini; Anton Früh; Michael Seidenstücker; Bodo Kurz; Hagen Schmal; Bernd Rolauffs
Journal:  Materials (Basel)       Date:  2021-05-20       Impact factor: 3.623

Review 5.  Chitosan based bioactive materials in tissue engineering applications-A review.

Authors:  Md Minhajul Islam; Md Shahruzzaman; Shanta Biswas; Md Nurus Sakib; Taslim Ur Rashid
Journal:  Bioact Mater       Date:  2020-02-12

6.  A Novel pH- and Salt-Responsive N-Succinyl-Chitosan Hydrogel via a One-Step Hydrothermal Process.

Authors:  Xingliang Li; Yihan Wang; Aoqi Li; Yingqing Ye; Shuhua Peng; Mingyu Deng; Bo Jiang
Journal:  Molecules       Date:  2019-11-20       Impact factor: 4.411

7.  Balancing biological and biomechanical performance in intervertebral disc repair: a systematic review of injectable cell delivery biomaterials.

Authors:  C J Panebianco; J H Meyers; J Gansau; W W Hom; J C Iatridis
Journal:  Eur Cell Mater       Date:  2020-11-18       Impact factor: 3.942

Review 8.  Relationship between Structure and Rheology of Hydrogels for Various Applications.

Authors:  Gorjan Stojkov; Zafarjon Niyazov; Francesco Picchioni; Ranjita K Bose
Journal:  Gels       Date:  2021-12-09
  8 in total

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