Literature DB >> 30250905

Feedback regulation of mitochondrial homeostasis via Wnt/β-catenin signaling.

Dominic B Bernkopf1, Jürgen Behrens1.   

Abstract

Cellular abundance of mitochondria is dynamically regulated. We could recently show that dysfunctional mitochondria release the phosphatase PGAM family member 5 (PGAM5) into the cytosol, where it interacts with the Wnt signaling-component AXIN1 and dephosphorylates AXIN1-bound β-catenin (CTNNB1) thereby activating Wnt/β-catenin signaling. Because Wnt/β-catenin signaling induces mitochondrial biogenesis dysfunctional mitochondria trigger their own replacement by releasing PGAM5.

Entities:  

Keywords:  AXIN1; PGAM5; Wnt signaling; mitochondria; β-catenin

Year:  2018        PMID： 30250905      PMCID： PMC6149705          DOI： 10.1080/23723556.2018.1458015

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Wnt/β-catenin signaling and disease.

Authors:  Hans Clevers; Roel Nusse
Journal:  Cell       Date:  2012-06-08       Impact factor: 41.582

2.  LiCl regulates mitochondrial biogenesis during megakaryocyte development.

Authors:  Ram Babu Undi; Usha Gutti; Ravi Kumar Gutti
Journal:  J Trace Elem Med Biol       Date:  2016-10-11       Impact factor: 3.849

Review 3.  Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis.

Authors:  Konstantinos Palikaras; Nektarios Tavernarakis
Journal:  Exp Gerontol       Date:  2014-01-28       Impact factor: 4.032

4.  Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

Authors:  John C Yoon; Aylwin Ng; Brian H Kim; Antonio Bianco; Ramnik J Xavier; Stephen J Elledge
Journal:  Genes Dev       Date:  2010-07-15       Impact factor: 11.361

5.  Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

Authors:  Shiori Sekine; Yusuke Kanamaru; Masato Koike; Ayako Nishihara; Masahiro Okada; Hideyuki Kinoshita; Miki Kamiyama; Junichi Maruyama; Yasuo Uchiyama; Naotada Ishihara; Kohsuke Takeda; Hidenori Ichijo
Journal:  J Biol Chem       Date:  2012-08-22       Impact factor: 5.157

6.  A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy.

Authors:  Guo Chen; Zhe Han; Du Feng; Yanfang Chen; Linbo Chen; Hao Wu; Li Huang; Changqian Zhou; Xiangyu Cai; Changying Fu; Liangwei Duan; Xiaohui Wang; Lei Liu; Xinqi Liu; Yuequan Shen; Yushan Zhu; Quan Chen
Journal:  Mol Cell       Date:  2014-04-17       Impact factor: 17.970

Review 7.  AMPK: guardian of metabolism and mitochondrial homeostasis.

Authors:  Sébastien Herzig; Reuben J Shaw
Journal:  Nat Rev Mol Cell Biol       Date:  2017-10-04       Impact factor: 94.444

8.  Genetic deficiency of the mitochondrial protein PGAM5 causes a Parkinson's-like movement disorder.

Authors:  Wei Lu; Senthilkumar S Karuppagounder; Danielle A Springer; Michele D Allen; Lixin Zheng; Brittany Chao; Yan Zhang; Valina L Dawson; Ted M Dawson; Michael Lenardo
Journal:  Nat Commun       Date:  2014-09-15       Impact factor: 14.919

9.  Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling.

Authors:  Dominic B Bernkopf; Kowcee Jalal; Martina Brückner; Karl X Knaup; Marc Gentzel; Alexandra Schambony; Jürgen Behrens
Journal:  J Cell Biol       Date:  2018-02-08       Impact factor: 10.539
  9 in total
  4 in total

Review 1.  Perspectives on Wnt Signal Pathway in the Pathogenesis and Therapeutics of Chronic Obstructive Pulmonary Disease.

Authors:  Jiao Qu; Li Yue; Jian Gao; Hongwei Yao
Journal:  J Pharmacol Exp Ther       Date:  2019-04-05       Impact factor: 4.030

Review 2.  The influence of mitochondrial-directed regulation of Wnt signaling on tumorigenesis.

Authors:  Yaritza Delgado-Deida; Kibrom M Alula; Arianne L Theiss
Journal:  Gastroenterol Rep (Oxf)       Date:  2020-06-15

3.  Exploiting pyocyanin to treat mitochondrial disease due to respiratory complex III dysfunction.

Authors:  Roberta Peruzzo; Samantha Corrà; Roberto Costa; Michele Brischigliaro; Tatiana Varanita; Lucia Biasutto; Chiara Rampazzo; Daniele Ghezzi; Luigi Leanza; Mario Zoratti; Massimo Zeviani; Cristiano De Pittà; Carlo Viscomi; Rodolfo Costa; Ildikò Szabò
Journal:  Nat Commun       Date:  2021-04-08       Impact factor: 17.694

Review 4.  Mitochondrial Metabolism, Contact Sites and Cellular Calcium Signaling: Implications for Tumorigenesis.

Authors:  Roberta Peruzzo; Roberto Costa; Magdalena Bachmann; Luigi Leanza; Ildikò Szabò
Journal:  Cancers (Basel)       Date:  2020-09-10       Impact factor: 6.639
  4 in total

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