Literature DB >> 30250897

Cell fate in colon cancer stem cells: To GLI or not to GLI?

Joseph L Regan1,2.   

Abstract

Colon cancer is a heterogeneous tumor driven by subpopulations of cancer stem cells (CSCs). We recently used patient-derived organoids (PDOs) to demonstrate that CSC survival is regulated by autocrine non-canonical Hedgehog signaling, which acts as a positive regulator of Wnt signaling to block CSC differentiation.

Entities:  

Keywords:  Cancer Organoid; Cancer Stem Cell; Colon Cancer; Non-canonical Hedgehog signaling; WNT pathway

Year:  2018        PMID： 30250897      PMCID： PMC6149873          DOI： 10.1080/23723556.2018.1445940

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy.

Authors:  Li Song; Zhuo-Yu Li; Wei-Ping Liu; Mei-Rong Zhao
Journal:  Cancer Biol Ther       Date:  2015       Impact factor: 4.742

2.  Epithelial hedgehog signals pattern the intestinal crypt-villus axis.

Authors:  Blair B Madison; Katherine Braunstein; Erlene Kuizon; Kathleen Portman; Xiaotan T Qiao; Deborah L Gumucio
Journal:  Development       Date:  2004-12-08       Impact factor: 6.868

Review 3.  Noncanonical Hedgehog signaling.

Authors:  Donna Brennan; Xiaole Chen; Lan Cheng; My Mahoney; Natalia A Riobo
Journal:  Vitam Horm       Date:  2012       Impact factor: 3.421

4.  Non-Canonical Hedgehog Signaling Is a Positive Regulator of the WNT Pathway and Is Required for the Survival of Colon Cancer Stem Cells.

Authors:  Joseph L Regan; Dirk Schumacher; Stephanie Staudte; Andreas Steffen; Johannes Haybaeck; Ulrich Keilholz; Caroline Schweiger; Nicole Golob-Schwarzl; Dominik Mumberg; David Henderson; Hans Lehrach; Christian R A Regenbrecht; Reinhold Schäfer; Martin Lange
Journal:  Cell Rep       Date:  2017-12-05       Impact factor: 9.423

5.  Canonical Wnt signals are essential for homeostasis of the intestinal epithelium.

Authors:  Daniel Pinto; Alex Gregorieff; Harry Begthel; Hans Clevers
Journal:  Genes Dev       Date:  2003-07-15       Impact factor: 11.361

6.  Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

Authors:  L V Goodrich; R L Johnson; L Milenkovic; J A McMahon; M P Scott
Journal:  Genes Dev       Date:  1996-02-01       Impact factor: 11.361

7.  A randomized phase II trial of vismodegib versus placebo with FOLFOX or FOLFIRI and bevacizumab in patients with previously untreated metastatic colorectal cancer.

Authors:  Jordan Berlin; Johanna C Bendell; Lowell L Hart; Irfan Firdaus; Ira Gore; Robert C Hermann; Mary F Mulcahy; Mark M Zalupski; Howard M Mackey; Robert L Yauch; Richard A Graham; Gordon L Bray; Jennifer A Low
Journal:  Clin Cancer Res       Date:  2012-10-18       Impact factor: 12.531

Review 8.  Cancer stem cells--old concepts, new insights.

Authors:  L Vermeulen; M R Sprick; K Kemper; G Stassi; J P Medema
Journal:  Cell Death Differ       Date:  2008-02-15       Impact factor: 15.828

9.  Hedgehog Acyltransferase as a target in estrogen receptor positive, HER2 amplified, and tamoxifen resistant breast cancer cells.

Authors:  Armine Matevossian; Marilyn D Resh
Journal:  Mol Cancer       Date:  2015-04-01       Impact factor: 27.401

10.  Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma.

Authors:  E Petrova; A Matevossian; M D Resh
Journal:  Oncogene       Date:  2014-01-27       Impact factor: 9.867
  10 in total
  1 in total

1.  RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence.

Authors:  Joseph L Regan; Dirk Schumacher; Stephanie Staudte; Andreas Steffen; Ralf Lesche; Joern Toedling; Thibaud Jourdan; Johannes Haybaeck; Dominik Mumberg; David Henderson; Balázs Győrffy; Christian R A Regenbrecht; Ulrich Keilholz; Reinhold Schäfer; Martin Lange
Journal:  iScience       Date:  2021-05-24
  1 in total

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