Literature DB >> 25692617

Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy.

Li Song1, Zhuo-Yu Li, Wei-Ping Liu, Mei-Rong Zhao.   

Abstract

Wnt/β-catenin and Hedgehog/Gli signalings play key roles in multiple biogenesis such as embryonic development and tissue homeostasis. Dysregulations of these 2 pathways are frequently found in most cancers, particularly in colon cancer. Their crosstalk has been increasingly appreciated as an important mechanism in regulating colon cancer progression. Our studies into the link between Wnt/β-catenin and Hedgehog/Gli signalings in colon cancer revealed several possible crosstalk points and suggested potential therapeutic strategies for colon cancer.

Entities:  

Keywords:  Gli; Hedgehog/Gli signaling; Wnt/β-catenin signaling; colon cancer; crosstalk; therapeutic targets; β-catenin

Mesh：

Substances：

Year:  2015        PMID： 25692617      PMCID： PMC4622601          DOI： 10.4161/15384047.2014.972215

Source DB:  PubMed          Journal:  Cancer Biol Ther        ISSN： 1538-4047            Impact factor:   4.742


  76 in total

1.  WNT antagonist, SFRP1, is Hedgehog signaling target.

Authors:  Yuriko Katoh; Masaru Katoh
Journal:  Int J Mol Med       Date:  2006-01       Impact factor: 4.101

2.  Evidence for the direct involvement of {beta}TrCP in Gli3 protein processing.

Authors:  Baolin Wang; Yanyun Li
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-21       Impact factor: 11.205

3.  Hedgehog Wnteraction in colorectal cancer.

Authors:  G R van den Brink; J C H Hardwick
Journal:  Gut       Date:  2006-07       Impact factor: 23.059

4.  Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP.

Authors:  Denis Tempé; Mariana Casas; Sonia Karaz; Marie-Françoise Blanchet-Tournier; Jean-Paul Concordet
Journal:  Mol Cell Biol       Date:  2006-06       Impact factor: 4.272

5.  Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production.

Authors:  Mattias Ormestad; Jeanette Astorga; Henrik Landgren; Tao Wang; Bengt R Johansson; Naoyuki Miura; Peter Carlsson
Journal:  Development       Date:  2006-01-26       Impact factor: 6.868

6.  Expression of hedgehog pathway components in the adult colon.

Authors:  Gijs R Van Den Brink; Maikel P Peppelenbosch
Journal:  Gastroenterology       Date:  2006-02       Impact factor: 22.682

7.  P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin.

Authors:  Liuqing Yang; Chunru Lin; Zhi-Ren Liu
Journal:  Cell       Date:  2006-10-06       Impact factor: 41.582

8.  Association of the ERK1/2 and p38 kinase pathways with nitric oxide-induced apoptosis and cell cycle arrest in colon cancer cells.

Authors:  H-K Jeon; S-u Choi; N-P Jung
Journal:  Cell Biol Toxicol       Date:  2005-03       Impact factor: 6.691

9.  Enhancement of GLI1-transcriptional activity by beta-catenin in human cancer cells.

Authors:  Osamu Maeda; Masashi Kondo; Takayoshi Fujita; Noriyasu Usami; Takayuki Fukui; Kaoru Shimokata; Takafumi Ando; Hidemi Goto; Yoshitaka Sekido
Journal:  Oncol Rep       Date:  2006-07       Impact factor: 3.906

10.  Antisense gene therapy using anti-k-ras and antitelomerase oligonucleotides in colorectal cancer.

Authors:  S Lledó; R Alfonso; S F Aliño
Journal:  Rev Esp Enferm Dig       Date:  2005-07       Impact factor: 2.086
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  41 in total

1.  Noncalcemic Vitamin D Hydroxyderivatives Inhibit Human Oral Squamous Cell Carcinoma and Down-regulate Hedgehog and WNT/β-Catenin Pathways.

Authors:  Allen S W Oak; Georgeta Bocheva; Tae-Kang Kim; Anna A Brożyna; Zorica Janjetovic; Mohammad Athar; Robert C Tuckey; Andrzej T Slominski
Journal:  Anticancer Res       Date:  2020-05       Impact factor: 2.480

2.  Genomic analysis of synchronous intracranial meningiomas with different histological grades.

Authors:  Tamrin Chowdhury; Yongjin Yoo; Youngbeom Seo; Yun-Sik Dho; Sojin Kim; Anna Choi; Murim Choi; Sung-Hye Park; Chul-Kee Park; Sang Hyung Lee; Ji Yeoun Lee
Journal:  J Neurooncol       Date:  2018-02-08       Impact factor: 4.130

Review 3.  Targeting the Wnt/beta-catenin pathway in cancer: Update on effectors and inhibitors.

Authors:  Nithya Krishnamurthy; Razelle Kurzrock
Journal:  Cancer Treat Rev       Date:  2017-11-13       Impact factor: 12.111

Review 4.  The utility of stem cells in pediatric urinary bladder regeneration.

Authors:  Philip M Iannaccone; Vasil Galat; Matthew I Bury; Yongchao C Ma; Arun K Sharma
Journal:  Pediatr Res       Date:  2017-11-08       Impact factor: 3.756

5.  GSK-3 modulates SHH-driven proliferation in postnatal cerebellar neurogenesis and medulloblastoma.

Authors:  Jennifer K Ocasio; Rolf Dale P Bates; Carolyn D Rapp; Timothy R Gershon
Journal:  Development       Date:  2019-10-10       Impact factor: 6.868

6.  Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.

Authors:  Nicolas Aznar; Jason Ear; Ying Dunkel; Nina Sun; Kendall Satterfield; Fang He; Nicholas A Kalogriopoulos; Inmaculada Lopez-Sanchez; Majid Ghassemian; Debashis Sahoo; Irina Kufareva; Pradipta Ghosh
Journal:  Sci Signal       Date:  2018-02-27       Impact factor: 8.192

7.  Cell fate in colon cancer stem cells: To GLI or not to GLI?

Authors:  Joseph L Regan
Journal:  Mol Cell Oncol       Date:  2018-04-19

8.  Repigmentation of Human Vitiligo Skin by NBUVB Is Controlled by Transcription of GLI1 and Activation of the β-Catenin Pathway in the Hair Follicle Bulge Stem Cells.

Authors:  Nathaniel B Goldstein; Maranke I Koster; Kenneth L Jones; Bifeng Gao; Laura G Hoaglin; Steven E Robinson; Michael J Wright; Smaranda I Birlea; Abigail Luman; Karoline A Lambert; Yiqun G Shellman; Mayumi Fujita; William A Robinson; Dennis R Roop; David A Norris; Stanca A Birlea
Journal:  J Invest Dermatol       Date:  2017-10-17       Impact factor: 8.551

Review 9.  Interplay between morphogen-directed positional information systems and physiological signaling.

Authors:  Francisco Huizar; Dharsan Soundarrajan; Ramezan Paravitorghabeh; Jeremiah Zartman
Journal:  Dev Dyn       Date:  2019-12-20       Impact factor: 3.780

10.  Wnt3a-regulated TCF4/β-catenin complex directly activates the key Hedgehog signalling genes Smo and Gli1.

Authors:  Youpei Wang; Peipei Lin; Qing Wang; Meiqin Zheng; Lingxia Pang
Journal:  Exp Ther Med       Date:  2018-06-29       Impact factor: 2.447
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