Literature DB >> 30250889

Escaping NK cells and recruiting neutrophils: How Morgana/NF-κB signaling promotes metastasis.

Federica Fusella1, Laura Seclì1, Mara Brancaccio1.   

Abstract

Cancer cells escape immune surveillance and induce immune cell aberrant activation to support tumour growth and progression. We recently reported that Morgana/NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) signaling in breast cancer cells is responsible for NK (Natural Killer) cell inactivation and neutrophil recruitment in the primary tumour and in the lung pre-metastatic niche.

Entities:  

Keywords:  Morgana; NF-κB; Natural Killer cells; breast cancer metastasis; neutrophils

Year:  2018        PMID： 30250889      PMCID： PMC6150045          DOI： 10.1080/23723556.2018.1432258

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Microenvironmental regulation of tumor progression and metastasis.

Authors:  Daniela F Quail; Johanna A Joyce
Journal:  Nat Med       Date:  2013-11       Impact factor: 53.440

2.  Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.

Authors:  Federica Fusella; Roberta Ferretti; Daniele Recupero; Stefania Rocca; Augusta Di Savino; Giusy Tornillo; Lorenzo Silengo; Emilia Turco; Sara Cabodi; Paolo Provero; Pier Paolo Pandolfi; Anna Sapino; Guido Tarone; Mara Brancaccio
Journal:  J Pathol       Date:  2014-08-06       Impact factor: 7.996

Review 3.  Morgana and melusin: two fairies chaperoning signal transduction.

Authors:  Roberta Ferretti; Mauro Sbroggiò; Augusta Di Savino; Federica Fusella; Alessandro Bertero; Wojciech Michowski; Guido Tarone; Mara Brancaccio
Journal:  Cell Cycle       Date:  2011-11-01       Impact factor: 4.534

Review 4.  NK cells and cancer: you can teach innate cells new tricks.

Authors:  Maelig G Morvan; Lewis L Lanier
Journal:  Nat Rev Cancer       Date:  2016-01       Impact factor: 60.716

Review 5.  Breast cancer metastasis: markers and models.

Authors:  Britta Weigelt; Johannes L Peterse; Laura J van 't Veer
Journal:  Nat Rev Cancer       Date:  2005-08       Impact factor: 60.716

Review 6.  Pre-metastatic niches: organ-specific homes for metastases.

Authors:  Héctor Peinado; Haiying Zhang; Irina R Matei; Bruno Costa-Silva; Ayuko Hoshino; Goncalo Rodrigues; Bethan Psaila; Rosandra N Kaplan; Jacqueline F Bromberg; Yibin Kang; Mina J Bissell; Thomas R Cox; Amato J Giaccia; Janine T Erler; Sachie Hiratsuka; Cyrus M Ghajar; David Lyden
Journal:  Nat Rev Cancer       Date:  2017-03-17       Impact factor: 60.716

Review 7.  Neutrophils in cancer: neutral no more.

Authors:  Seth B Coffelt; Max D Wellenstein; Karin E de Visser
Journal:  Nat Rev Cancer       Date:  2016-06-10       Impact factor: 60.716

Review 8.  The double face of Morgana in tumorigenesis.

Authors:  Mara Brancaccio; Stefania Rocca; Laura Seclì; Elena Busso; Federica Fusella
Journal:  Oncotarget       Date:  2015-12-15

Review 9.  The complexity of NF-κB signaling in inflammation and cancer.

Authors:  Bastian Hoesel; Johannes A Schmid
Journal:  Mol Cancer       Date:  2013-08-02       Impact factor: 27.401

10.  The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.

Authors:  Federica Fusella; Laura Seclì; Elena Busso; Anna Krepelova; Enrico Moiso; Stefania Rocca; Laura Conti; Laura Annaratone; Cristina Rubinetto; Maurizia Mello-Grand; Vijay Singh; Giovanna Chiorino; Lorenzo Silengo; Fiorella Altruda; Emilia Turco; Alessandro Morotti; Salvatore Oliviero; Isabella Castellano; Federica Cavallo; Paolo Provero; Guido Tarone; Mara Brancaccio
Journal:  Nat Commun       Date:  2017-11-21       Impact factor: 14.919
  10 in total
  1 in total

Review 1.  Dissecting pharmacological effects of chloroquine in cancer treatment: interference with inflammatory signaling pathways.

Authors:  Lokman Varisli; Osman Cen; Spiros Vlahopoulos
Journal:  Immunology       Date:  2019-12-22       Impact factor: 7.397
  1 in total

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