| Literature DB >> 28303905 |
Héctor Peinado1,2, Haiying Zhang1, Irina R Matei1, Bruno Costa-Silva1,3, Ayuko Hoshino1, Goncalo Rodrigues1,4, Bethan Psaila5, Rosandra N Kaplan6, Jacqueline F Bromberg7, Yibin Kang8,9, Mina J Bissell10, Thomas R Cox11, Amato J Giaccia12, Janine T Erler13, Sachie Hiratsuka14, Cyrus M Ghajar15, David Lyden1,16.
Abstract
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.Entities:
Mesh：
Year: 2017 PMID： 28303905 DOI： 10.1038/nrc.2017.6
Source DB: PubMed Journal: Nat Rev Cancer ISSN： 1474-175X Impact factor: 60.716