T Chapron1, G Mimoun1,2, A Miere1, M Srour1, A El Ameen1, O Semoun1, E H Souied3,4. 1. Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris XII, Créteil, France. 2. Centre Ophtalmologique d'Imagerie de l'Ecole Militaire, Paris, France. 3. Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris XII, Créteil, France. eric.souied@chicreteil.fr. 4. University of Paris-Est-Créteil-Val-de-Marne, Créteil, France. eric.souied@chicreteil.fr.
Abstract
PURPOSE: To characterize the features of choroidal neovascularization (CNV) secondary to angioid streaks (AS) with optical coherence tomography angiography (OCT-A) and to assess its sensitivity in CNV detection in this particular context. METHODS: Consecutive patients, both with treatment-naïve and recurrent CNV associated with angioid streaks were prospectively analyzed. All patients underwent macular imaging by fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain (SD)-OCT, and OCT-A (AngioVue, Optovue, Optovue Inc., Freemont, CA, USA). OCT-A detection rate of CNV associated to AS was evaluated by two independent observers. We studied the association between OCT-A feature and either exudative or active status using Fisher exact test. RESULTS: A total of 32 eyes of 18 consecutive patients were included in the analysis. OCT-A was able to detect CNV associated with angioid streaks in 87.5 % (28/32) eyes. OCT-A phenotypes of CNV were classified into interlacing pattern in 9 eyes, pruned vascular tree pattern in 7 eyes, and combined pattern in 12 eyes (Interuser agreement: 0.871 ± 0.071). CNV were not detectable in 4/32 eyes. There was a statistically significant association between the presence in OCT-A of densely ramified networks with both previous treatment status in the last 6 months (p < 0.001) and with exudative signs on SD-OCT (p = 0.014). CONCLUSION: OCT-A appears as a sensitive tool for detection of CNV secondary to AS. The interlacing pattern was significantly associated with active and exudative features.
PURPOSE: To characterize the features of choroidal neovascularization (CNV) secondary to angioid streaks (AS) with optical coherence tomography angiography (OCT-A) and to assess its sensitivity in CNV detection in this particular context. METHODS: Consecutive patients, both with treatment-naïve and recurrent CNV associated with angioid streaks were prospectively analyzed. All patients underwent macular imaging by fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain (SD)-OCT, and OCT-A (AngioVue, Optovue, Optovue Inc., Freemont, CA, USA). OCT-A detection rate of CNV associated to AS was evaluated by two independent observers. We studied the association between OCT-A feature and either exudative or active status using Fisher exact test. RESULTS: A total of 32 eyes of 18 consecutive patients were included in the analysis. OCT-A was able to detect CNV associated with angioid streaks in 87.5 % (28/32) eyes. OCT-A phenotypes of CNV were classified into interlacing pattern in 9 eyes, pruned vascular tree pattern in 7 eyes, and combined pattern in 12 eyes (Interuser agreement: 0.871 ± 0.071). CNV were not detectable in 4/32 eyes. There was a statistically significant association between the presence in OCT-A of densely ramified networks with both previous treatment status in the last 6 months (p < 0.001) and with exudative signs on SD-OCT (p = 0.014). CONCLUSION:OCT-A appears as a sensitive tool for detection of CNV secondary to AS. The interlacing pattern was significantly associated with active and exudative features.
Authors: Laura Kuehlewein; Mayank Bansal; Tamara L Lenis; Nicholas A Iafe; SriniVas R Sadda; Marco A Bonini Filho; Talisa E De Carlo; Nadia K Waheed; Jay S Duker; David Sarraf Journal: Am J Ophthalmol Date: 2015-07-09 Impact factor: 5.258
Authors: Yali Jia; Ou Tan; Jason Tokayer; Benjamin Potsaid; Yimin Wang; Jonathan J Liu; Martin F Kraus; Hrebesh Subhash; James G Fujimoto; Joachim Hornegger; David Huang Journal: Opt Express Date: 2012-02-13 Impact factor: 3.894
Authors: Hoang Mai Le; Eric H Souied; Safa Halouani; Enrico Borrelli; Thibaut Chapron; Giuseppe Querques; Alexandra Miere Journal: J Clin Med Date: 2022-04-11 Impact factor: 4.964