Literature DB >> 3025015

The second pX product p27 chi-III of HTLV-1 is required for gag gene expression.

J Inoue, M Seiki, M Yoshida.   

Abstract

The human T-cell leukemia virus type-1 (HTLV-1) contains a unique pX region, which encodes the gene products p40 chi, p27 chi-III and p21 chi-III. p40 chi is required for transcriptional trans-activation, whereas p27 chi-III and p21 chi-III have no such function. Transfection of pX expression plasmids containing different combinations for the three gene products into cells integrated with HTLV-1 proviruses defective in pX expression revealed that both p40 chi and p27 chi-III are required for expression of the gag protein and accumulation of gag mRNA. These observations suggest that the pX product p40 chi activates transcription and p27 chi-III controls the level of gag mRNA by post-transcriptional modulation.

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Year:  1986        PMID： 3025015     DOI： 10.1016/0014-5793(86)81108-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  40 in total

1.  Mutational analysis of the human T-cell leukemia virus type I trans-acting rex gene product.

Authors:  L Hofer; I Weichselbraun; S Quick; G K Farrington; E Böhnlein; J Hauber
Journal:  J Virol       Date:  1991-06       Impact factor: 5.103

Review 2.  The human T-cell leukemia virus Rex protein.

Authors:  Ihab Younis; Patrick L Green
Journal:  Front Biosci       Date:  2005-01-01

3.  Extensive sequence-specific information throughout the CAR/RRE, the target sequence of the human immunodeficiency virus type 1 Rev protein.

Authors:  E T Dayton; D A Konings; D M Powell; B A Shapiro; L Butini; J V Maizel; A I Dayton
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

4.  Protein kinase A-dependent binding of a nuclear factor to the 21-base-pair repeat of the human T-cell leukemia virus type I long terminal repeat.

Authors:  H T Poteat; F Y Chen; P Kadison; J G Sodroski; W A Haseltine
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

5.  Human T-cell leukemia virus type 1 pX-I and pX-II open reading frames are dispensable for the immortalization of primary lymphocytes.

Authors:  M D Robek; F H Wong; L Ratner
Journal:  J Virol       Date:  1998-05       Impact factor: 5.103

6.  Nucleolar targeting signal of human T-cell leukemia virus type I rex-encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA.

Authors:  T Nosaka; H Siomi; Y Adachi; M Ishibashi; S Kubota; M Maki; M Hatanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

7.  Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes.

Authors:  J Inoue; M Yoshida; M Seiki
Journal:  Proc Natl Acad Sci U S A       Date:  1987-06       Impact factor: 11.205

Review 8.  The origin and evolution of human T-cell lymphotropic virus types I and II.

Authors:  Y Suzuki; T Gojobori
Journal:  Virus Genes       Date:  1998       Impact factor: 2.332

Review 9.  T-cell control by human T-cell leukemia/lymphoma virus type 1.

Authors:  Genoveffa Franchini; Risaku Fukumoto; Jake R Fullen
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.490

10.  The Rev protein of human immunodeficiency virus type 1 promotes polysomal association and translation of gag/pol and vpu/env mRNAs.

Authors:  D M D'Agostino; B K Felber; J E Harrison; G N Pavlakis
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272
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