Literature DB >> 30250

Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats.

E Siemkowicz, A J Hansen.   

Abstract

Rats with different levels of blood glucose concentration were exposed to 10 min of complete brain ischemia achieved by compression of neck vessels by a pneumatic cuff. All normoglycemic rats survived the ischemic period and made the best clinical recovery. Hyperglycemic rats died within 12 h. Seizure activity was observed in all animals in this group. Three of eight hypoglycemic rats died between 3 and 16 days. The clinical recovery was less complete than in the control group. Thus, recovery from cerebral ischemia depends upon preischemic blood glucose concentration. Hyper- and hypoglycemia hamper the clinical recovery after transient cerebral ischemia.

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Year:  1978        PMID： 30250

Source DB:  PubMed          Journal:  Acta Neurol Scand        ISSN： 0001-6314            Impact factor:   3.209


  38 in total

1.  Insulin protects cognitive function in experimental stroke.

Authors:  A J Strong; J E Fairfield; E Monteiro; M Kirby; A R Hogg; M Snape; L Ross-Field
Journal:  J Neurol Neurosurg Psychiatry       Date:  1990-10       Impact factor: 10.154

2.  High blood glucose does not adversely affect outcome in moderately brain-injured rodents.

Authors:  Julia Hill; Jing Zhao; Pramod K Dash
Journal:  J Neurotrauma       Date:  2010-08       Impact factor: 5.269

3.  Frontal cortex lesion prior to hyperglycemic ischemia: no decrease in ensuing substantia nigra pars reticulata damage or fatal post-ischemic seizures.

Authors:  J Lundgren; M Ingvar; M L Smith; B K Siesjö
Journal:  Exp Brain Res       Date:  1992       Impact factor: 1.972

4.  Crossover effects of acidosis on the recovery of neuronal function following glucose-oxygen deprivation in rat hippocampal slices.

Authors:  Y Morimoto; T Yamamura; O Kemmotsu
Journal:  J Anesth       Date:  1994-09       Impact factor: 2.078

5.  Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era.

Authors:  Fabrice Daviaud; Florence Dumas; Nadège Demars; Guillaume Geri; Adrien Bouglé; Tristan Morichau-Beauchant; Yên-Lan Nguyen; Wulfran Bougouin; Frédéric Pène; Julien Charpentier; Alain Cariou
Journal:  Intensive Care Med       Date:  2014-03-25       Impact factor: 17.440

6.  Stroke topography and outcome in relation to hyperglycaemia and diabetes.

Authors:  L Kiers; S M Davis; R Larkins; J Hopper; B Tress; S C Rossiter; J Carlin; S Ratnaike
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-04       Impact factor: 10.154

7.  Clinical predictors and management of hemorrhagic transformation.

Authors:  Raphaella E Weiser; Kevin N Sheth
Journal:  Curr Treat Options Neurol       Date:  2013-04       Impact factor: 3.598

8.  Brain lactic acidosis and ischemic cell damage: quantitative ultrastructural changes in capillaries of rat cerebral cortex.

Authors:  L Paljärvi; S Rehncrona; B Söderfeldt; Y Olsson; H Kalimo
Journal:  Acta Neuropathol       Date:  1983       Impact factor: 17.088

9.  Extracellular potassium and blood flow in the post-ischemic rat brain.

Authors:  A J Hansen; A Gjedde; E Siemkowicz
Journal:  Pflugers Arch       Date:  1980-12       Impact factor: 3.657

10.  Effects of emopamil on postischemic blood flow and neuronal damage in rat brain.

Authors:  G W Bielenberg; D Sauer; J Nuglisch; T Beck; C Rossberg; H D Mennel; J Krieglstein
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989 Jan-Feb       Impact factor: 3.000
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