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Literature DB >> 23325069

Clinical predictors and management of hemorrhagic transformation.

Abstract

OPINION STATEMENT: Hemorrhagic Transformation (HT) has been well recognized as a common cause of hemorrhage in ischemic stroke patients. Though this complication may occur independently, it has been particularly dreaded in the post rTPA patient and thus has been the focus for analysis of multiple thrombolytic trials. This review examines the effect of different clinical predictors for hemorrhagic transformation and summarizes pertinent clinical trials, with a focus on the rational for design of future studies. Although currently there are no official guidelines for the acute management of HT per se, based upon review of the literature regarding pertinent clinical predictors herein, an innovative approach for the acute management of the HT patient is proposed.

Entities: Disease Species

Year: 2013 PMID： 23325069 DOI： 10.1007/s11940-012-0217-2

Source DB: PubMed Journal: Curr Treat Options Neurol ISSN： 1092-8480 Impact factor: 3.598

44 in total

1. The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke.

Authors: Gustavo Saposnik; Jiming Fang; Moira K Kapral; Jack V Tu; Muhammad Mamdani; Peter Austin; S Claiborne Johnston
Journal: Stroke Date: 2012-02-03 Impact factor: 7.914

2. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production.

Authors: Seok Joon Won; Xian Nan Tang; Sang Won Suh; Midori A Yenari; Raymond A Swanson
Journal: Ann Neurol Date: 2011-10-14 Impact factor: 10.422

3. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study.

Authors: Eloy Cuadrado; Anna Rosell; Anna Penalba; Mark Slevin; José Alvarez-Sabín; Arantxa Ortega-Aznar; Joan Montaner
Journal: J Proteome Res Date: 2009-06 Impact factor: 4.466

4. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques.

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Journal: Am J Physiol Date: 1997-04

5. Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats.

Authors: E Siemkowicz; A J Hansen
Journal: Acta Neurol Scand Date: 1978-07 Impact factor: 3.209

Review 6. Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment.

Authors: Paul A Lapchak
Journal: Curr Neurol Neurosci Rep Date: 2002-01 Impact factor: 5.081

Review 7. Matrix metalloproteinases and processing of pro-TNF-alpha.

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Journal: J Leukoc Biol Date: 1995-05 Impact factor: 4.962

8. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat.

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Journal: Brain Res Date: 1998-06-08 Impact factor: 3.252

9. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

Authors: I Giardino; D Edelstein; M Brownlee
Journal: J Clin Invest Date: 1994-07 Impact factor: 14.808

Clinical predictors and management of hemorrhagic transformation.

1. The iScore predicts effectiveness of thrombolytic therapy for acute ischemic stroke.

2. Hyperglycemia promotes tissue plasminogen activator-induced hemorrhage by Increasing superoxide production.

3. Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study.

4. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques.

5. Clinical restitution following cerebral ischemia in hypo-, normo- and hyperglycemic rats.

Review 6. Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment.

Review 7. Matrix metalloproteinases and processing of pro-TNF-alpha.

8. Protective effects of free radical inhibitors in intracerebral hemorrhage in rat.

9. Nonenzymatic glycosylation in vitro and in bovine endothelial cells alters basic fibroblast growth factor activity. A model for intracellular glycosylation in diabetes.

Review 10. Matrix metalloproteinases in brain injury.

1. TURN Score Predicts 90-day Outcome in Acute Ischemic Stroke Patients After IV Thrombolysis.

2. Cohort-Based Identification of Predictors of Symptomatic Intracerebral Hemorrhage After IV Thrombolysis.

3. Comparison of 8 scores for predicting symptomatic intracerebral hemorrhage after IV thrombolysis.

4. TURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis.

Review 5. Hemorrhagic Transformation After Ischemic Stroke: Mechanisms and Management.