Literature DB >> 30249692

In Vivo Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model.

Aline da Graça Sampaio1,2, Aline Vidal Lacerda Gontijo3, Helena Marcolla Araujo2, Cristiane Yumi Koga-Ito1.   

Abstract

The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a Drosophila melanogaster model. Candida albicans bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in Drosophila melanogaster was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  Candida albicanszzm321990; Drosophila melanogasterzzm321990; candidiasis; ellagic acid

Mesh：

Substances：

Year:  2018        PMID： 30249692      PMCID： PMC6256789          DOI： 10.1128/AAC.01716-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  9 in total

1.  Guidelines for treatment of candidiasis.

Authors:  Peter G Pappas; John H Rex; Jack D Sobel; Scott G Filler; William E Dismukes; Thomas J Walsh; John E Edwards
Journal:  Clin Infect Dis       Date:  2003-12-19       Impact factor: 9.079

2.  The estimation of the bactericidal power of the blood.

Authors:  A A Miles; S S Misra; J O Irwin
Journal:  J Hyg (Lond)       Date:  1938-11

Review 3.  Epidemiology of invasive candidiasis: a persistent public health problem.

Authors:  M A Pfaller; D J Diekema
Journal:  Clin Microbiol Rev       Date:  2007-01       Impact factor: 26.132

4.  Plant extracts: initial screening, identification of bioactive compounds and effect against Candida albicans biofilms.

Authors:  Fernanda Lourenção Brighenti; Marcos José Salvador; Aline Vidal Lacerda Gontijo; Alberto Carlos Botazzo Delbem; Ádina Cléia Botazzo Delbem; Cristina Pacheco Soares; Maria Alcionéiac Carvalho de Oliveira; Camila Miorelli Girondi; Cristiane Yumi Koga-Ito
Journal:  Future Microbiol       Date:  2016-12-06       Impact factor: 3.165

5.  Antifungal activity of extracts and isolated compounds from Buchenavia tomentosa on Candida albicans and non-albicans.

Authors:  Guilherme R Teodoro; Fernanda L Brighenti; Alberto C Botazzo Delbem; Ádina Cléia B Delbem; Sonia Khouri; Aline Vidal L Gontijo; Aislan Crf Pascoal; Marcos J Salvador; Cristiane Y Koga-Ito
Journal:  Future Microbiol       Date:  2015       Impact factor: 3.165

6.  Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species.

Authors:  Georgios Chamilos; Michail S Lionakis; Russell E Lewis; Jose L Lopez-Ribot; Stephen P Saville; Nathaniel D Albert; Georg Halder; Dimitrios P Kontoyiannis
Journal:  J Infect Dis       Date:  2006-02-28       Impact factor: 5.226

7.  Mycobacterium marinum infection in Drosophila melanogaster for antimycobacterial activity assessment.

Authors:  Chun-Taek Oh; Cheol Moon; Tae Hyun Choi; Byoung Soo Kim; Jichan Jang
Journal:  J Antimicrob Chemother       Date:  2012-11-01       Impact factor: 5.790

8.  Wild-type Drosophila melanogaster as an alternative model system for investigating the pathogenicity of Candida albicans.

Authors:  Marcus T Glittenberg; Sukrit Silas; Donna M MacCallum; Neil A R Gow; Petros Ligoxygakis
Journal:  Dis Model Mech       Date:  2011-05-02       Impact factor: 5.758

9.  The Lantibiotic NAI-107 Efficiently Rescues Drosophila melanogaster from Infection with Methicillin-Resistant Staphylococcus aureus USA300.

Authors:  Thomas T Thomsen; Biljana Mojsoska; João C S Cruz; Stefano Donadio; Håvard Jenssen; Anders Løbner-Olesen; Kim Rewitz
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191
  9 in total
  2 in total

1.  Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the Systemic Cryptococcus neoformans Infection in Leukopenic Mice.

Authors:  Masood Alam Khan; Arif Khan; Mohd Azam; Khaled S Allemailem; Faris Alrumaihi; Ahmad Almatroudi; Fahad A Alhumaydhi; Faizul Azam; Shaheer Hasan Khan; Syeda Fauzia Farheen Zofair; Sumbul Ahmad; Hina Younus
Journal:  Pharmaceutics       Date:  2021-06-15       Impact factor: 6.321

2.  Ellagic Acid Inhibits Trichophyton rubrum Growth via Affecting Ergosterol Biosynthesis and Apoptotic Induction.

Authors:  Zhi-Jian Li; Amima Abula; Abudumijiti Abulizi; Chun Wang; Qin Dou; Youlidouzi Maimaiti; Abudoujilili Abudouaini; Shi-Xia Huo; Silafu Aibai
Journal:  Evid Based Complement Alternat Med       Date:  2020-10-27       Impact factor: 2.629
  2 in total

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