Guilherme R Teodoro1, Fernanda L Brighenti2, Alberto C Botazzo Delbem3, Ádina Cléia B Delbem3, Sonia Khouri4, Aline Vidal L Gontijo5,6, Aislan Crf Pascoal6, Marcos J Salvador6, Cristiane Y Koga-Ito1,5. 1. Oral Biopathology Graduate Program, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil. 2. Department of Orthodontics & Pediatric Dentistry, Araraquara Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil. 3. Department of Pediatric Dentistry, Araçatuba Dental School, Universidade Estadual Paulista (UNESP), São Paulo, Brazil. 4. Faculdade de Ciências da Saúde, Universidade do Vale do Paraíba (UNIVAP), São José dos Campos, São Paulo, Brazil. 5. Department of Environmental Engineering, São José dos Campos Institute of Science & Technology, Universidade Estadual Paulista/UNESP, São Paulo, Brazil. 6. Department of Plant Biology, PPGBTPB, Institute of Biology, Universidade Estadual de Campinas (UNICAMP), São Paulo, Brazil.
Abstract
AIM: This study aimed to evaluate the antifungal activity of Buchenavia tomentosa extract and bioactive compounds on six Candida species. MATERIALS & METHODS: The antimicrobial activity of extract was evaluated using standard strains and clinical isolates. Cytotoxicity was tested in order to evaluate cell damage caused by the extract. Extract was chemically characterized and the antifungal activity of its compounds was evaluated. RESULTS: Extract showed antifungal activity on Candida species. Candida non-albicans were more susceptible than Candida albicans. Low cytotoxicity for extract was observed. The isolated compounds presented antifungal activity at least against one Candida spp. and all compounds presented antifungal effect on Candida glabrata. CONCLUSION: Extracts from Buchenavia tomentosa showed promising antifungal activity on Candida species with low cytotoxicity. Gallic acid, corilagin and ellagic acid showed promising inhibitory activity on Candida glabrata.
AIM: This study aimed to evaluate the antifungal activity of Buchenavia tomentosa extract and bioactive compounds on six Candida species. MATERIALS & METHODS: The antimicrobial activity of extract was evaluated using standard strains and clinical isolates. Cytotoxicity was tested in order to evaluate cell damage caused by the extract. Extract was chemically characterized and the antifungal activity of its compounds was evaluated. RESULTS: Extract showed antifungal activity on Candida species. Candida non-albicans were more susceptible than Candida albicans. Low cytotoxicity for extract was observed. The isolated compounds presented antifungal activity at least against one Candida spp. and all compounds presented antifungal effect on Candida glabrata. CONCLUSION: Extracts from Buchenavia tomentosa showed promising antifungal activity on Candida species with low cytotoxicity. Gallic acid, corilagin and ellagic acid showed promising inhibitory activity on Candida glabrata.
Authors: Guilherme R Teodoro; Aline V L Gontijo; Marcos J Salvador; Márcia H Tanaka; Fernanda L Brighenti; Alberto C B Delbem; Ádina C B Delbem; Cristiane Y Koga-Ito Journal: Front Microbiol Date: 2018-04-05 Impact factor: 5.640
Authors: Tiago Fonseca Silva; José Robson Neves Cavalcanti Filho; Mariana Mirelle Lima Barreto Fonsêca; Natalia Medeiros Dos Santos; Ana Carolina Barbosa da Silva; Adrielle Zagmignan; Afonso Gomes Abreu; Ana Paula Sant'Anna da Silva; Vera Lúcia de Menezes Lima; Nicácio Henrique da Silva; Lívia Macedo Dutra; Jackson Roberto Guedes da Silva Almeida; Márcia Vanusa da Silva; Maria Tereza Dos Santos Correia; Luís Cláudio Nascimento da Silva Journal: Pharmaceuticals (Basel) Date: 2020-03-16