Literature DB >> 30248524

Combined use of live-attenuated and inactivated influenza vaccines to enhance heterosubtypic protection.

Li-Meng Yan1, Olive T W Li1, Chek M Poh1, Ranawaka A P M Perera1, Sophie A Valkenburg2, Malik Peiris1, Leo L M Poon3.   

Abstract

The limited protection of current commerical vaccines necessitates the investigation of novel vaccine strategies for unpredictable outbreaks. To investigate the feasibility of using vaccines derived from Group 1 influenza A virus to induce broadly cross-reactive immune responses against multiple influenza subtypes, we tested a panel of sequential 4-dose immunization regimens in mice. Mice were treated with inactivated (seasonal H1N1, pandemic H1N1 and H5N1) and vaccinia virus-based H5N1 live-attenuated vaccines in different combinations. Mice were then challenged by viruses of either Group 1 (H1N1) or Group 2 (H3N2, H7N7) influenza virus. All studied sequential 4-dose vaccinations could induce some degrees of heterosubtypic protection in mice. Amongst all these regimens, the combined use of inactivated and live-attenuated vaccines could achieve the best heterologous protection. These results highlight the synergistic effect of combining different vaccine platforms to enhance heterosubtypic protection against influenza viruses.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Heterosubtypic immunity; Influenza; Universal vaccine

Mesh：

Substances：

Year:  2018        PMID： 30248524      PMCID： PMC6275109          DOI： 10.1016/j.virol.2018.09.007

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  37 in total

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Review 3.  Functions of CD8 T-cell subsets secreting different cytokine patterns.

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Authors:  S Sad; D Kägi; T R Mosmann
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Review 10.  Improving the selection and development of influenza vaccine viruses - Report of a WHO informal consultation on improving influenza vaccine virus selection, Hong Kong SAR, China, 18-20 November 2015.

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Journal:  Vaccine       Date:  2017-01-25       Impact factor: 3.641
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  2 in total

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Journal:  mBio       Date:  2020-03-03       Impact factor: 7.867

2.  Chimeric Hemagglutinin-Based Live-Attenuated Vaccines Confer Durable Protective Immunity against Influenza A Viruses in a Preclinical Ferret Model.

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Journal:  Vaccines (Basel)       Date:  2021-01-11
  2 in total

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