Adela Hruby1,2, Shivani Sahni3,4, Douglas Bolster5, Paul F Jacques1,2. 1. Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts. 2. The Friedman School of Nutrition Science and Policy, Boston, Massachusetts. 3. Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts. 4. Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. 5. Research and Innovation, Danone North America, Louisville, Colorado.
Abstract
BACKGROUND: Higher protein intake is linked to maintenance of muscle mass and strength, but few studies have related protein to physical function and disability in aging. METHODS: In participants of the Framingham Heart Study Offspring, we examined associations between protein intake (g/d), estimated from food frequency questionnaires, and maintenance of functional integrity, as a functional integrity score based on responses to 17 questions from Katz Activities of Daily Living, Nagi, and Rosow-Breslau questionnaires, repeated up to five times (1991/1995-2011/2014) over 23 years of follow-up. Cox proportional hazard models were used to estimate risk of incident loss of functional integrity (functional integrity score ≤ 15th percentile). RESULTS: In 2,917 participants (age 54.5 [9.8] years), baseline protein intake was 77.2 (15.6) g/d. The functional integrity score (baseline, mean 98.9, range 82.4-100.0) was associated with objective performance (gait speed, grip strength) and lower odds of falls, fractures, and frailty. Across follow-up, there were 731 incident cases of loss of functional integrity. In fully adjusted models, participants in the highest category of protein intake (median 92.2 g/d) had 30% lower risk of loss of functional integrity (hazard ratio [95% confidence interval] 0.70 [0.52, 0.95], p trend = .03), versus those with the lowest intake (median 64.4 g/d). However, sex-stratified analyses indicated the association was driven by the association in women alone (hazard ratio [95% confidence interval] 0.49 [0.32, 0.74], p trend = .002) and was nonsignificant in men (hazard ratio [95% confidence interval] 1.14 [0.70, 1.86], p trend = .59). CONCLUSIONS: Higher protein intake was beneficially associated with maintenance of physical function in middle-aged, high-functioning U.S. adults over the span of two decades. This association was particularly evident in women.
BACKGROUND: Higher protein intake is linked to maintenance of muscle mass and strength, but few studies have related protein to physical function and disability in aging. METHODS: In participants of the Framingham Heart Study Offspring, we examined associations between protein intake (g/d), estimated from food frequency questionnaires, and maintenance of functional integrity, as a functional integrity score based on responses to 17 questions from Katz Activities of Daily Living, Nagi, and Rosow-Breslau questionnaires, repeated up to five times (1991/1995-2011/2014) over 23 years of follow-up. Cox proportional hazard models were used to estimate risk of incident loss of functional integrity (functional integrity score ≤ 15th percentile). RESULTS: In 2,917 participants (age 54.5 [9.8] years), baseline protein intake was 77.2 (15.6) g/d. The functional integrity score (baseline, mean 98.9, range 82.4-100.0) was associated with objective performance (gait speed, grip strength) and lower odds of falls, fractures, and frailty. Across follow-up, there were 731 incident cases of loss of functional integrity. In fully adjusted models, participants in the highest category of protein intake (median 92.2 g/d) had 30% lower risk of loss of functional integrity (hazard ratio [95% confidence interval] 0.70 [0.52, 0.95], p trend = .03), versus those with the lowest intake (median 64.4 g/d). However, sex-stratified analyses indicated the association was driven by the association in women alone (hazard ratio [95% confidence interval] 0.49 [0.32, 0.74], p trend = .002) and was nonsignificant in men (hazard ratio [95% confidence interval] 1.14 [0.70, 1.86], p trend = .59). CONCLUSIONS: Higher protein intake was beneficially associated with maintenance of physical function in middle-aged, high-functioning U.S. adults over the span of two decades. This association was particularly evident in women.
Authors: Eftychia Kotronia; S Goya Wannamethee; A Olia Papacosta; Peter H Whincup; Lucy T Lennon; Marjolein Visser; Robert J Weyant; Tamara B Harris; Sheena E Ramsay Journal: J Am Med Dir Assoc Date: 2019-08-10 Impact factor: 4.669
Authors: Tara S Rogers-Soeder; Katherine E Peters; Nancy E Lane; James M Shikany; Suzanne Judd; Lisa Langsetmo; Andrew R Hoffman; William J Evans; Peggy M Cawthon Journal: J Gerontol A Biol Sci Med Sci Date: 2020-06-18 Impact factor: 6.053
Authors: Liset E M Elstgeest; Laura A Schaap; Martijn W Heymans; Linda M Hengeveld; Elke Naumann; Denise K Houston; Stephen B Kritchevsky; Eleanor M Simonsick; Anne B Newman; Samaneh Farsijani; Marjolein Visser; Hanneke A H Wijnhoven Journal: Am J Clin Nutr Date: 2020-07-01 Impact factor: 7.045
Authors: L Langsetmo; S Harrison; S Jonnalagadda; S L Pereira; J M Shikany; S Farsijani; N E Lane; J A Cauley; K Stone; P M Cawthon Journal: J Nutr Health Aging Date: 2020 Impact factor: 4.075
Authors: Nuno Mendonça; Linda M Hengeveld; Marjolein Visser; Nancy Presse; Helena Canhão; Eleanor M Simonsick; Stephen B Kritchevsky; Anne B Newman; Pierrette Gaudreau; Carol Jagger Journal: Am J Clin Nutr Date: 2021-07-01 Impact factor: 7.045