Sara Alcorn1, Kristina Nilsson2, Avani D Rao1, Matthew M Ladra1, Ralph P Ermoian3, Rosangela C Villar4, Michael J Chen5, Daria Kobyzeva6, Alexey V Nechesnyuk6, Eric Ford3, Shannon MacDonald7, Brian Winey7, Karin Dieckmann8, Stephanie A Terezakis1. 1. Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins School of Medicine, Baltimore, MD. 2. Department of Oncology, Uppsala University Hospital, Uppsala, Sweden. 3. Department of Radiation Oncology, University of Washington, Seattle, WA. 4. Department of Radiation Oncology, Centro Infantil Boldrini, São Paulo e Região. 5. Department of Radiation, Grupo de Apoio ao Adolescente e à Criança com Câncer, São Paulo, Brazil. 6. Department of Radiotherapy, Federal Scientific Clinical Centre of Children's Hematology, Oncology and Immunology, Moscow, Russia. 7. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA. 8. Department of Radiation Oncology, Universität Klinik Für Strahlentherapie und Strahlenbiologie, Vienna, Austria.
Abstract
PURPOSE/ OBJECTIVES: There is little consensus regarding the application of stereotactic radiotherapy (SRT) in pediatrics. We evaluated patterns of pediatric SRT practice through an international research consortium. MATERIALS AND METHODS: Eight international institutions with pediatric expertise completed a 124-item survey evaluating patterns of SRT use for patients 21 years old and younger. Frequencies of SRT use and median margins applied with and without SRT were evaluated. RESULTS: Across institutions, 75% reported utilizing SRT in pediatrics. SRT was used in 22% of brain, 18% of spine, 16% of other bone, 16% of head and neck, and <1% of abdomen/pelvis, lung, and liver cases across sites. Of the hypofractionated SRT cases, 42% were delivered with definitive intent. Median gross tumor volume to planning target volume margins for SRT versus non-SRT plans were 0.2 versus 1.4 cm for brain, 0.3 versus 1.5 cm for spine/other bone, 0.3 versus 2.0 cm for abdomen/pelvis, 0.7 versus 1.5 cm for head and neck, 0.5 versus 1.7 cm for lung, and 0.5 versus 2.0 cm for liver sites. CONCLUSIONS: SRT is commonly utilized in pediatrics across a range of treatment sites. Margins used for SRT were substantially smaller than for non-SRT planning, highlighting the utility of this approach in reducing treatment volumes.
PURPOSE/ OBJECTIVES: There is little consensus regarding the application of stereotactic radiotherapy (SRT) in pediatrics. We evaluated patterns of pediatric SRT practice through an international research consortium. MATERIALS AND METHODS: Eight international institutions with pediatric expertise completed a 124-item survey evaluating patterns of SRT use for patients 21 years old and younger. Frequencies of SRT use and median margins applied with and without SRT were evaluated. RESULTS: Across institutions, 75% reported utilizing SRT in pediatrics. SRT was used in 22% of brain, 18% of spine, 16% of other bone, 16% of head and neck, and <1% of abdomen/pelvis, lung, and liver cases across sites. Of the hypofractionated SRT cases, 42% were delivered with definitive intent. Median gross tumor volume to planning target volume margins for SRT versus non-SRT plans were 0.2 versus 1.4 cm for brain, 0.3 versus 1.5 cm for spine/other bone, 0.3 versus 2.0 cm for abdomen/pelvis, 0.7 versus 1.5 cm for head and neck, 0.5 versus 1.7 cm for lung, and 0.5 versus 2.0 cm for liver sites. CONCLUSIONS: SRT is commonly utilized in pediatrics across a range of treatment sites. Margins used for SRT were substantially smaller than for non-SRT planning, highlighting the utility of this approach in reducing treatment volumes.
Authors: Christopher L Tinkle; Charu Singh; Shane Lloyd; Yian Guo; Yimei Li; Alberto S Pappo; Steven G DuBois; John T Lucas; Daphne A Haas-Kogan; Stephanie A Terezakis; Steve E Braunstein; Matthew J Krasin Journal: Int J Radiat Oncol Biol Phys Date: 2020-11-28 Impact factor: 7.038
Authors: Sebastian Adeberg; Christina Sauer; Lena Lambert; Sebastian Regnery; Paul Windisch; Karim Zaoui; Christian Freudlsperger; Julius Moratin; Benjamin Farnia; Christoph Nikendei; Juergen Krauss; Johannes C Ehrenthal; Rami El Shafie; Juliane Hörner-Rieber; Laila König; Sati Akbaba; Kristin Lang; Thomas Held; Stefan Rieken; Juergen Debus; Hans-Christoph Friederich; Imad Maatouk Journal: Front Psychol Date: 2021-12-16