Zeqin Fan1, Xiaoxia Lu1, Hong Long1, Taoping Li1, Yanhong Zhang2. 1. Sleep Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. 2. Health Care Center, Guangdong Entry-exit Inspection and Quarantine Bureau, Guangzhou, China.
Abstract
BACKGROUND: The hemocyte profile is one of the most frequently requested clinical laboratory tests. However, the analysis of blood cell indexes of obstructive sleep apnea (OSA) patients in previous studies was not comprehensive. And, this study aimed to fully analyze the blood routine in OSA patients. METHODS: A retrospective study was conducted on 1087 male patients, who were admitted to the sleep center of Nanfang Hospital from May 2013 to February 2018. According to the apnea hypopnea index (AHI), patients were divided into four groups: control group (AHI < 5, n = 135), mild OSA (5 ≦ AHI < 15, n = 185), moderate OSA (15 ≦ AHI < 30, n = 171), and severe OSA (AHI ≧ 30, n = 596). Data collected included sleep parameters, complete blood routine, body mass index (BMI), age, and comorbidities. RESULTS: In our study, leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocytes, hemoglobin, hematocrit, platelets, MPV, and PDW-SD were statistically significant among the four groups based on AHI (P < 0.05), but no significant differences were found in MCV, RDW-SD, N/L, and P/L ratio (P > 0.05). Neutrophils, lymphocytes, monocytes, eosinophils, basophils, hemoglobin, hematocrit, platelets, and MPV were significantly correlated with AHI. Moreover, multiple linear regression analysis demonstrated that hematocrit (β = 73.254, P = 0.001), neutrophils (β = 1.414, P = 0.012), and lymphocytes (β = 4.228, P < 0.001) were independently associated with AHI. CONCLUSION: Neutrophils, lymphocytes, and hematocrit were independently associated with OSA severity. And combining these three blood cell indicators could contribute to the diagnosis of OSA.
BACKGROUND: The hemocyte profile is one of the most frequently requested clinical laboratory tests. However, the analysis of blood cell indexes of obstructive sleep apnea (OSA) patients in previous studies was not comprehensive. And, this study aimed to fully analyze the blood routine in OSA patients. METHODS: A retrospective study was conducted on 1087 male patients, who were admitted to the sleep center of Nanfang Hospital from May 2013 to February 2018. According to the apnea hypopnea index (AHI), patients were divided into four groups: control group (AHI < 5, n = 135), mild OSA (5 ≦ AHI < 15, n = 185), moderate OSA (15 ≦ AHI < 30, n = 171), and severe OSA (AHI ≧ 30, n = 596). Data collected included sleep parameters, complete blood routine, body mass index (BMI), age, and comorbidities. RESULTS: In our study, leukocytes, neutrophils, lymphocytes, monocytes, eosinophils, basophils, erythrocytes, hemoglobin, hematocrit, platelets, MPV, and PDW-SD were statistically significant among the four groups based on AHI (P < 0.05), but no significant differences were found in MCV, RDW-SD, N/L, and P/L ratio (P > 0.05). Neutrophils, lymphocytes, monocytes, eosinophils, basophils, hemoglobin, hematocrit, platelets, and MPV were significantly correlated with AHI. Moreover, multiple linear regression analysis demonstrated that hematocrit (β = 73.254, P = 0.001), neutrophils (β = 1.414, P = 0.012), and lymphocytes (β = 4.228, P < 0.001) were independently associated with AHI. CONCLUSION: Neutrophils, lymphocytes, and hematocrit were independently associated with OSA severity. And combining these three blood cell indicators could contribute to the diagnosis of OSA.
Authors: P G Gibson; J Dolovich; A Girgis-Gabardo; M M Morris; M Anderson; F E Hargreave; J A Denburg Journal: Clin Exp Allergy Date: 1990-11 Impact factor: 5.018
Authors: Mako Nagayoshi; Naresh M Punjabi; Elizabeth Selvin; James S Pankow; Eyal Shahar; Hiroyasu Iso; Aaron R Folsom; Pamela L Lutsey Journal: Sleep Med Date: 2016-09-29 Impact factor: 3.492
Authors: Daniel Morell-Garcia; Núria Toledo-Pons; Pilar Sanchis; Josep Miquel Bauça; José María Sánchez; José Peña-Zarza; Paloma Giménez; Javier Pierola; Mónica de la Peña-Bravo; Alberto Alonso-Fernández; Antònia Barceló Journal: ERJ Open Res Date: 2020-10-05
Authors: Oshin Miranda; Peihao Fan; Xiguang Qi; Zeshui Yu; Jian Ying; Haohan Wang; David A Brent; Jonathan C Silverstein; Yu Chen; Lirong Wang Journal: J Pers Med Date: 2022-03-24