Isabel F Ramos1, Christine M Guardino2, Maxwell Mansolf3, Laura M Glynn4, Curt A Sandman5, Calvin J Hobel6, Christine Dunkel Schetter7. 1. University of California, Los Angeles, United States. Electronic address: isabelramos@ucla.edu. 2. Dickinson College, United States. 3. University of California, Los Angeles, United States. 4. Chapman University, United States; University of California, Irvine, United States. 5. University of California, Irvine, United States. 6. University of California, Los Angeles, United States; Cedars-Sinai Medical Center, United States. 7. University of California, Los Angeles, United States. Electronic address: dunkel@psych.ucla.edu.
Abstract
OBJECTIVE: Previous research has shown that a woman's anxiety about her pregnancy predicts gestational length. Placental corticotrophin-releasing hormone (CRH) is a stress-responsive peptide proposed as a mechanism. We examined placental CRH as a physiological mediator of the association between pregnancy anxiety and gestational length in Latina and non-Latina White women to replicate evidence of associations between pregnancy anxiety, placental CRH and gestational length; to test whether placental CRH levels or changes mediate effects of pregnancy anxiety on gestational length; to examine ethnic differences in pregnancy anxiety, placental CRH, and gestational length; and to explore whether the effects of pregnancy anxiety on gestational length as mediated by placental CRH vary by ethnicity. METHODS: In a prospective study of 337 pregnant Latina and non-Latina White women, participants completed in-person interviews that included a 10-item measure of pregnancy anxiety and provided blood samples assayed using radioimmunoassay at three timepoints (19, 25, and 31 weeks gestation). RESULTS: Pregnancy anxiety at 19 and 31 weeks and levels of placental CRH at 31 weeks predicted gestational length. Tests of indirect effects were consistent with mediation such that both pregnancy anxiety at 19 weeks and increases from 19 to 31 weeks predicted placental CRH at 31 weeks, which in turn predicted gestational length. Tests of moderated mediation by ethnicity showed that the mediated effect of placental CRH at 31 weeks was significant for Latinas only. CONCLUSIONS: These findings add to growing evidence of the involvement of pregnancy anxiety in the timing of birth, address mechanisms, and suggest possible ethnic differences.
OBJECTIVE: Previous research has shown that a woman's anxiety about her pregnancy predicts gestational length. Placental corticotrophin-releasing hormone (CRH) is a stress-responsive peptide proposed as a mechanism. We examined placental CRH as a physiological mediator of the association between pregnancy anxiety and gestational length in Latina and non-Latina White women to replicate evidence of associations between pregnancy anxiety, placental CRH and gestational length; to test whether placental CRH levels or changes mediate effects of pregnancy anxiety on gestational length; to examine ethnic differences in pregnancy anxiety, placental CRH, and gestational length; and to explore whether the effects of pregnancy anxiety on gestational length as mediated by placental CRH vary by ethnicity. METHODS: In a prospective study of 337 pregnant Latina and non-Latina White women, participants completed in-person interviews that included a 10-item measure of pregnancy anxiety and provided blood samples assayed using radioimmunoassay at three timepoints (19, 25, and 31 weeks gestation). RESULTS:Pregnancy anxiety at 19 and 31 weeks and levels of placental CRH at 31 weeks predicted gestational length. Tests of indirect effects were consistent with mediation such that both pregnancy anxiety at 19 weeks and increases from 19 to 31 weeks predicted placental CRH at 31 weeks, which in turn predicted gestational length. Tests of moderated mediation by ethnicity showed that the mediated effect of placental CRH at 31 weeks was significant for Latinas only. CONCLUSIONS: These findings add to growing evidence of the involvement of pregnancy anxiety in the timing of birth, address mechanisms, and suggest possible ethnic differences.
Authors: Marci Lobel; Dolores Lacey Cannella; Jennifer E Graham; Carla DeVincent; Jayne Schneider; Bruce A Meyer Journal: Health Psychol Date: 2008-09 Impact factor: 4.267
Authors: Mariann A Howland; Curt A Sandman; Laura M Glynn; Cheryl Crippen; Elysia Poggi Davis Journal: Psychoneuroendocrinology Date: 2016-02-04 Impact factor: 4.905
Authors: Jacquelyn L Hill; M Karen Campbell; Guang Yong Zou; John R G Challis; Gregor Reid; Hiroshi Chisaka; Alan D Bocking Journal: Am J Obstet Gynecol Date: 2008-04 Impact factor: 8.661
Authors: Simon Schmitt; Kai G Ringwald; Tina Meller; Frederike Stein; Katharina Brosch; Julia-Katharina Pfarr; Tim Hahn; Hannah Lemke; Susanne Meinert; Jonathan Repple; Katharina Thiel; Lena Waltemate; Alexandra Winter; Dominik Grotegerd; Astrid Dempfle; Andreas Jansen; Axel Krug; Udo Dannlowski; Igor Nenadić; Tilo Kircher Journal: Eur Arch Psychiatry Clin Neurosci Date: 2022-07-29 Impact factor: 5.760
Authors: Anne S J Farina; Kristen P Kremer; Sarah Caldera Wimmer; Tatiana Villarreal-Otálera; Tania Paredes; Emily Stuart Journal: J Immigr Minor Health Date: 2020-09-27
Authors: Hudson P Santos; Harry Adynski; Rebeca Harris; Arjun Bhattacharya; Angela C Incollingo Rodriguez; Ryan Cali; Alessandra Torres Yabar; Benjamin C Nephew; Christopher Murgatroyd Journal: J Affect Disord Date: 2020-12-31 Impact factor: 4.839
Authors: Mona Hashim; Ayla Coussa; Ayesha S Al Dhaheri; Amina Al Marzouqi; Samer Cheaib; Anastasia Salame; Dima O Abu Jamous; Farah Naja; Hayder Hasan; Lily Stojanovska; Maysm N Mohamad; Mo'ath F Bataineh; MoezAlIslam E Faris; Rameez Al Daour; Reyad S Obaid; Sheima T Saleh; Tareq M Osaili; Leila Cheikh Ismail Journal: BMC Pregnancy Childbirth Date: 2021-07-19 Impact factor: 3.007