Literature DB >> 30244335

New study suggests patients with advanced prostate cancer on androgen deprivation therapy need more dialogue with health care provider, especially around cardiovascular risk.

Axel Merseburger1, Anne Bro Falkenberg2, Olga J Kornilova3.   

Abstract

PURPOSE: To study the current level of patients' awareness, and patient-health care provider (HCP) dialogue with respect to treatment-related risks, especially cardiovascular risk (CVR) associated with advanced prostate cancer (PCa) treatment.
METHODS: This 10-min online survey summarised data by treatment, region, and CVR (high or low).
RESULTS: Of the 411 patients, 83% were at high CVR while only 8% patients were aware of CVR associated with PCa treatment, majority of which (80%) were informed about this risk by HCPs. No significant difference in treatment approach was reported, regardless of patient's CVR status. Compared to other potential risks, patients were more likely to initiate discussion about heart problems with HCPs (38% patients). When prompted, 26% patients rated heart problems as the most concerning risk factor, and this concern was twice in patients with high CVR (28%) versus low CVR (14%). Lifestyle modifications were made by 64% patients, of which 45% patients reported an improvement in overall well-being. Improved diet was the most adopted lifestyle modification.
CONCLUSION: There is a need to enhance a constant patient-HCP dialogue, and both groups need to make a conscious effort in that direction. This would help in increasing patients' awareness of risks, having better treatment choice and acceptance, and reducing side-effects.

Entities:  

Keywords:  Cardiovascular risk; Hormone therapy; Online survey; Patient–physician discussions; Prostate cancer

Mesh:

Substances:

Year:  2018        PMID: 30244335     DOI: 10.1007/s00345-018-2495-0

Source DB:  PubMed          Journal:  World J Urol        ISSN: 0724-4983            Impact factor:   4.226


  30 in total

1.  Does comorbidity influence the risk of myocardial infarction or diabetes during androgen-deprivation therapy for prostate cancer?

Authors:  Nancy L Keating; A James O'Malley; Stephen J Freedland; Matthew R Smith
Journal:  Eur Urol       Date:  2012-04-19       Impact factor: 20.096

2.  Cardiovascular mortality in patients with metastatic prostate cancer exposed to androgen deprivation therapy: a population-based study.

Authors:  Giorgio Gandaglia; Maxine Sun; Ioana Popa; Jonas Schiffmann; Vincent Trudeau; Shahrokh F Shariat; Quoc-Dien Trinh; Markus Graefen; Hugues Widmer; Fred Saad; Alberto Briganti; Francesco Montorsi; Pierre I Karakiewicz
Journal:  Clin Genitourin Cancer       Date:  2014-12-09       Impact factor: 2.872

3.  Absolute and relative risk of cardiovascular disease in men with prostate cancer: results from the Population-Based PCBaSe Sweden.

Authors:  Mieke Van Hemelrijck; Hans Garmo; Lars Holmberg; Erik Ingelsson; Ola Bratt; Anna Bill-Axelson; Mats Lambe; Pär Stattin; Jan Adolfsson
Journal:  J Clin Oncol       Date:  2010-06-21       Impact factor: 44.544

4.  Cardiovascular comorbidity and treatment regret in men with recurrent prostate cancer.

Authors:  Paul L Nguyen; Ming-Hui Chen; Karen E Hoffman; Ronald C Chen; Jim C Hu; Charles L Bennett; Michael W Kattan; Oliver Sartor; Karen Stein; Anthony V D'Amico
Journal:  BJU Int       Date:  2011-11-15       Impact factor: 5.588

5.  Epidemiology of prostate cancer: current status.

Authors:  Z-Q Tao; A-M Shi; K-X Wang; W-D Zhang
Journal:  Eur Rev Med Pharmacol Sci       Date:  2015       Impact factor: 3.507

Review 6.  [Cardiovascular risks with prostate cancer hormonal treatment: rationale for a department of oncocardiology].

Authors:  I Latorzeff; G Ploussard; J Guillotreau; F Jonca; P Labarthe; G Rollin; J-B Beauval; A Pathak
Journal:  Cancer Radiother       Date:  2016-06-22       Impact factor: 1.018

7.  Androgen deprivation therapy for localized prostate cancer and the risk of cardiovascular mortality.

Authors:  Henry K Tsai; Anthony V D'Amico; Natalia Sadetsky; Ming-Hui Chen; Peter R Carroll
Journal:  J Natl Cancer Inst       Date:  2007-10-09       Impact factor: 13.506

8.  The value of patient-doctor dialog in the treatment of early prostate cancer.

Authors:  R O Fourcade; P Mensink; B Ernemo; C Ligensa
Journal:  Prostate Cancer Prostatic Dis       Date:  2002       Impact factor: 5.554

9.  The Prevalence of Cardiac Risk Factors in Men with Localized Prostate Cancer Undergoing Androgen Deprivation Therapy in British Columbia, Canada.

Authors:  Margot K Davis; Jennifer L Rajala; Scott Tyldesley; Tom Pickles; Sean A Virani
Journal:  J Oncol       Date:  2015-08-02       Impact factor: 4.375

10.  Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study.

Authors:  Reina Haque; Marianne UlcickasYood; Xiaoqing Xu; Andrea E Cassidy-Bushrow; Huei-Ting Tsai; Nancy L Keating; Stephen K Van Den Eeden; Arnold L Potosky
Journal:  Br J Cancer       Date:  2017-08-24       Impact factor: 7.640

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