Michael D Wood1, David M Maslove2, John Muscedere3, Stephen H Scott4, J Gordon Boyd5. 1. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada. Electronic address: 14mdw@queensu.ca. 2. Department of Critical Care Medicine, Queen's University, Kingston Health Sciences Centre, Kingston, ON, Canada. Electronic address: david.maslove@queensu.ca. 3. Department of Critical Care Medicine, Queen's University, Kingston Health Sciences Centre, Kingston, ON, Canada. Electronic address: muscedej@kgh.kari.net. 4. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada; Department of Medicine (Neurology), Queen's University, Kingston Health Sciences Centre, Kingston, ON, Canada. Electronic address: steve.scott@queensu.ca. 5. Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada; Department of Critical Care Medicine, Queen's University, Kingston Health Sciences Centre, Kingston, ON, Canada; Department of Medicine (Neurology), Queen's University, Kingston Health Sciences Centre, Kingston, ON, Canada. Electronic address: boydj@kgh.kari.net.
Abstract
PURPOSE: To assess the feasibility of using an integrated multimodal data collection strategy to characterize the post-intensive care syndrome (PICS). MATERIALS AND METHODS: Adult patients admitted to the ICU requiring invasive mechanical ventilation for >24 h and/or requiring vasopressor support were eligible for enrollment. We assessed cognitive and sensorimotor function at 3- and 12-months after ICU discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and with the KINARM robot. RESULTS: At 3- and 12-months after ICU discharge, 28/70 (40%) and 22/70 (31%) returned for follow-up testing, respectively. Prominent reasons for declining testing at 3- and 12-months included: not interested (40% and 38%) and health complications (31% and 31%). The majority of returning participants completed all tasks (96%-100%) and 100% of available data was recorded. On the RBANS, 54% (3 months) and 32% (12 months) of individuals were impaired in visuospatial/constructional skills. Similarly, the KINARM assessments demonstrated that 56% of individuals had visuospatial/executive dysfunction at 3 months, and 40% had impairment at 12 months. Individual scores indicated substantial variability. CONCLUSIONS: We demonstrated that it was feasible to quantify neurological dysfunction among participants that returned for follow-up testing. However, future investigations will need to implement multiple retention strategies. TRIAL REGISTRATION: This trial is registered on clinicaltrials.gov (Identifier: NCT02344043), retrospectively registered January 8, 2015. Crown
PURPOSE: To assess the feasibility of using an integrated multimodal data collection strategy to characterize the post-intensive care syndrome (PICS). MATERIALS AND METHODS: Adult patients admitted to the ICU requiring invasive mechanical ventilation for >24 h and/or requiring vasopressor support were eligible for enrollment. We assessed cognitive and sensorimotor function at 3- and 12-months after ICU discharge with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and with the KINARM robot. RESULTS: At 3- and 12-months after ICU discharge, 28/70 (40%) and 22/70 (31%) returned for follow-up testing, respectively. Prominent reasons for declining testing at 3- and 12-months included: not interested (40% and 38%) and health complications (31% and 31%). The majority of returning participants completed all tasks (96%-100%) and 100% of available data was recorded. On the RBANS, 54% (3 months) and 32% (12 months) of individuals were impaired in visuospatial/constructional skills. Similarly, the KINARM assessments demonstrated that 56% of individuals had visuospatial/executive dysfunction at 3 months, and 40% had impairment at 12 months. Individual scores indicated substantial variability. CONCLUSIONS: We demonstrated that it was feasible to quantify neurological dysfunction among participants that returned for follow-up testing. However, future investigations will need to implement multiple retention strategies. TRIAL REGISTRATION: This trial is registered on clinicaltrials.gov (Identifier: NCT02344043), retrospectively registered January 8, 2015. Crown
Authors: Catherine R Lowrey; Sean P Dukelow; Stephen D Bagg; Benjamin Ritsma; Stephen H Scott Journal: Neurorehabil Neural Repair Date: 2022-05-16 Impact factor: 4.895
Authors: Kimia Honarmand; Sabhyata Malik; Conor Wild; Laura E Gonzalez-Lara; Christopher W McIntyre; Adrian M Owen; Marat Slessarev Journal: PLoS One Date: 2019-04-12 Impact factor: 3.240
Authors: Michael D Wood; Jasmine Khan; Kevin F H Lee; David M Maslove; John Muscedere; Miranda Hunt; Stephen H Scott; Andrew Day; Jill A Jacobson; Ian Ball; Marat Slessarev; Niamh O'Regan; Shane W English; Victoria McCredie; Michaël Chasse; Donald Griesdale; J Gordon Boyd Journal: BMJ Open Date: 2019-06-25 Impact factor: 2.692