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Literature DB >> 3023885

An active chromatin structure acquired by translocated c-myc genes.

Abstract

We used general sensitivity to DNase I digestion to analyze the chromatin structure of c-myc genes in seven murine plasmacytomas. In every case, the 3' portion of c-myc juxtaposed with C alpha displayed a much more DNase I-sensitive chromatin structure than untranslocated c-myc or, in one case analyzed, the reciprocally translocated 5' portion. Our data suggest the presence of regulatory sequences near the C alpha gene segment.

Entities: Gene Species

Mesh：

Substances：

Year: 1986 PMID： 3023885 PMCID： PMC367653 DOI： 10.1128/mcb.6.4.1357-1361.1986

Source DB: PubMed Journal: Mol Cell Biol ISSN： 0270-7306 Impact factor: 4.272

46 in total

1. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Authors: G M Wahl; M Stern; G R Stark
Journal: Proc Natl Acad Sci U S A Date: 1979-08 Impact factor: 11.205

2. The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance.

Authors: X F Wang; K Calame
Journal: Cell Date: 1985-12 Impact factor: 41.582

Review 3. Active chromatin.

Authors: S Weisbrod
Journal: Nature Date: 1982-05-27 Impact factor: 49.962

Review 4. Chromatin.

Authors: T Igo-Kemenes; W Hörz; H G Zachau
Journal: Annu Rev Biochem Date: 1982 Impact factor: 23.643

5. Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

Authors: P W Early; M M Davis; D B Kaback; N Davidson; L Hood
Journal: Proc Natl Acad Sci U S A Date: 1979-02 Impact factor: 11.205

6. Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro.

Authors: F Rougeon; B Mach
Journal: Gene Date: 1977-05 Impact factor: 3.688

7. Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas.

Authors: S Crews; R Barth; L Hood; J Prehn; K Calame
Journal: Science Date: 1982-12-24 Impact factor: 47.728

8. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

Authors: C M Gorman; L F Moffat; B H Howard
Journal: Mol Cell Biol Date: 1982-09 Impact factor: 4.272

9. Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.

Authors: U Storb; R Wilson; E Selsing; A Walfield
Journal: Biochemistry Date: 1981-02-17 Impact factor: 3.162

An active chromatin structure acquired by translocated c-myc genes.

1. Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

2. The endogenous immunoglobulin heavy chain enhancer can activate tandem VH promoters separated by a large distance.

Review 3. Active chromatin.

Review 4. Chromatin.

5. Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.

6. Cloning and amplification of alpha and beta mouse globin gene sequences synthesised in vitro.

7. Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas.

8. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

9. Rearranged and germline immunoglobulin kappa genes: different states of DNase I sensitivity of constant kappa genes in immunocompetent and nonimmune cells.

10. Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells.

Review 1. Calcium, cyclic AMP and protein kinase C--partners in mitogenesis.

2. Strong transcriptional activation of translocated c-myc genes occurs without a strong nearby enhancer or promoter.

3. Selective removal of alpha heavy-chain glycosylation sites causes immunoglobulin A degradation and reduced secretion.

4. A plasmacytoma-specific factor binds the c-myc promoter region.

5. Germ line c-myc is not down-regulated by loss or exclusion of activating factors in myc-induced macrophage tumors.

6. Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver.

7. Mechanism of endogenous myc gene down-regulation in E mu-N-myc tumors.