Junling Fu1, Lanwen Han2, Yanglu Zhao3, Ge Li1, Yingna Zhu2, Yu Li1, Ming Li4, Shan Gao5, Steven M Willi6. 1. Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. 2. Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China. 3. Epidemiology Department, Fielding School of Public Health, University of California Los Angeles, Los Angeles 90024, USA. 4. Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. Electronic address: liming@pumch.cn. 5. Department of Endocrinology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100043, China. Electronic address: gaoshanmw@163.com. 6. Division of Endocrinology, The Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract
BACKGROUND AND AIMS: The relationship between vitamin D deficiency and metabolic syndrome (MS) remains controversial with relatively sparse data among youth. Therefore, we attempted to explicate the association of 25-hydroxyvitamin D [25(OH)D] levels with MS in Chinese adolescents and young adults. METHODS: A cohort of 559 subjects at elevated risk of MS were recruited at 14-28 years of age as a follow-up to the Beijing Child and Adolescent Metabolic Syndrome Study. Subjects underwent clinical assessment including a 2h-oral glucose tolerance test. The concentrations of 25(OH)D, glucose, insulin and lipids were determined. MS was defined using the 2009 harmonized definition. RESULTS: The prevalence of vitamin D deficiency (< 20 ng/ml) was 78.3%. After adjusting for age, gender and season, 25(OH)D concentrations were negatively correlated with neck circumference, percent body fat, LDL cholesterol, fasting and 2h-glucose levels (all P < 0.05). 25(OH)D levels were significantly lower in participants with obesity, high triglycerides, type 2 diabetes, or MS, compared to their respective counterparts (all P < 0.05). After adjusting for potential confounders (e.g., body mass index), participants in the lowest 25(OH)D tertile were 2.5 times more likely to exhibit MS than were those in the highest tertile (Odds Ratio: 2.48; 95% CI: 1.13-5.45, P < 0.05). CONCLUSIONS: Vitamin D deficiency was very common in this young Chinese population at risk for MS. Given this association between low vitamin D levels and MS, the role of vitamin D supplementation in Chinese youths needs further examination, particular in those at risk for MS.
BACKGROUND AND AIMS: The relationship between vitamin Ddeficiency and metabolic syndrome (MS) remains controversial with relatively sparse data among youth. Therefore, we attempted to explicate the association of 25-hydroxyvitamin D [25(OH)D] levels with MS in Chinese adolescents and young adults. METHODS: A cohort of 559 subjects at elevated risk of MS were recruited at 14-28 years of age as a follow-up to the Beijing Child and Adolescent Metabolic Syndrome Study. Subjects underwent clinical assessment including a 2h-oral glucose tolerance test. The concentrations of 25(OH)D, glucose, insulin and lipids were determined. MS was defined using the 2009 harmonized definition. RESULTS: The prevalence of vitamin Ddeficiency (< 20 ng/ml) was 78.3%. After adjusting for age, gender and season, 25(OH)D concentrations were negatively correlated with neck circumference, percent body fat, LDL cholesterol, fasting and 2h-glucose levels (all P < 0.05). 25(OH)D levels were significantly lower in participants with obesity, high triglycerides, type 2 diabetes, or MS, compared to their respective counterparts (all P < 0.05). After adjusting for potential confounders (e.g., body mass index), participants in the lowest 25(OH)D tertile were 2.5 times more likely to exhibit MS than were those in the highest tertile (Odds Ratio: 2.48; 95% CI: 1.13-5.45, P < 0.05). CONCLUSIONS:Vitamin Ddeficiency was very common in this young Chinese population at risk for MS. Given this association between low vitamin D levels and MS, the role of vitamin D supplementation in Chinese youths needs further examination, particular in those at risk for MS.
Authors: Ge Li; Ling Zhong; Lanwen Han; Yonghui Wang; Bo Li; Dongmei Wang; Yanglu Zhao; Yu Li; Qian Zhang; Lu Qi; John R Speakman; Steven M Willi; Ming Li; Shan Gao Journal: Int J Obes (Lond) Date: 2021-10-29 Impact factor: 5.551
Authors: Pei Xiao; Hongbo Dong; Haibo Li; Yinkun Yan; Hong Cheng; Junting Liu; Xiaoyuan Zhao; Dongqing Hou; Jie Mi Journal: BMJ Open Diabetes Res Care Date: 2020-02