Literature DB >> 3023098

Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate.

T Tsukiyama, T Hara, M Iio, G Kido, T Tsubokawa.   

Abstract

Regional cerebral turnover of 11C following intravenous injection of 11C-1-pyruvate was investigated in 12 patients with brain tumors. The positron emission tomography (PET) image taken at 10-15 min after the injection always demonstrated a high concentration of 11C in tumor, and thus visualized precise tumor contours. This phenomenon was not influenced qualitatively by the variation of blood flow in the tumor. Brain edema associated with the tumor was not visualized. We conclude that the localization of brain tumors would be well determined by the PET scan, using 11C-1-pyruvate.

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Year:  1986        PMID： 3023098     DOI： 10.1007/bf00251978

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  27 in total

1.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  L-lactate transport in Ehrlich ascites-tumour cells.

Authors:  T L Spencer; A L Lehninger
Journal:  Biochem J       Date:  1976-02-15       Impact factor: 3.857

3.  Brain tumor imaging by positron emission computed tomography using 11C-labeled amino acids.

Authors:  K F Hübner; J T Purvis; S M Mahaley; J T Robertson; S Rogers; W D Gibbs; P King; C L Partain
Journal:  J Comput Assist Tomogr       Date:  1982-06       Impact factor: 1.826

Review 4.  Intracellular pH.

Authors:  A Roos; W F Boron
Journal:  Physiol Rev       Date:  1981-04       Impact factor: 37.312

5.  pH distributions in transplanted neural tumors and normal tissues of BDIX rats as measured with pH microelectrodes.

Authors:  E Jähde; M F Rajewsky; H Baumgärtl
Journal:  Cancer Res       Date:  1982-04       Impact factor: 12.701

6.  Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.

Authors:  E Jähde; M F Rajewsky
Journal:  Cancer Res       Date:  1982-04       Impact factor: 12.701

7.  [Positron CT imaging with 13N-ammonia and 11C-carbon monoxide in intracranial tumors].

Authors:  F Shishido; Y Tateno; T Yamasaki; T Irie; O Inoue; K Tamate; K Suzuki; T Nakayama; T Takashima; A Yamaura; A Kurisu; H Ikehira
Journal:  Kaku Igaku       Date:  1982-08

8.  Positron emission tomography with ([11C]methyl)-L-methionine, [11C]D-glucose, and [68Ga]EDTA in supratentorial tumors.

Authors:  K Ericson; A Lilja; M Bergström; V P Collins; L Eriksson; E Ehrin; H von Holst; H Lundqvist; B Långsrom B; M Mosskin
Journal:  J Comput Assist Tomogr       Date:  1985 Jul-Aug       Impact factor: 1.826

9.  Difference of 14C turnovers in brain and in transplanted glioma after intravenous injection of 14C-1-pyruvate into rats.

Authors:  T Hara; F Yokoi
Journal:  Eur J Nucl Med       Date:  1986

10.  Dynamic positron emission tomography for study of cerebral hemodynamics in a cross section of the head using positron-emitting 68Ga-EDTA and 77Kr.

Authors:  Y L Yamamoto; C J Thompson; E Meyer; J S Robertson; W Feindel
Journal:  J Comput Assist Tomogr       Date:  1977-01       Impact factor: 1.826
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  2 in total

1.  Difference of 14C turnovers in brain and in transplanted glioma after intravenous injection of 14C-1-pyruvate into rats.

Authors:  T Hara; F Yokoi
Journal:  Eur J Nucl Med       Date:  1986

2.  Positron emission tomography using pyruvate-1-11C in two cases of mitochondrial encephalomyopathy.

Authors:  M Toyoda; N Sakuragawa; Y Arai; H Yoshikawa; K Sugai; M Arima; T Hara; M Iio; E Satoyoshi
Journal:  Ann Nucl Med       Date:  1989-07       Impact factor: 2.668
  2 in total

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