Literature DB >> 2641450

Positron emission tomography using pyruvate-1-11C in two cases of mitochondrial encephalomyopathy.

M Toyoda1, N Sakuragawa, Y Arai, H Yoshikawa, K Sugai, M Arima, T Hara, M Iio, E Satoyoshi.   

Abstract

Positron emission tomography (PET) using pyruvate-1-11C was carried out to investigate the in vivo metabolism of pyruvate in the brains of patients with mitochondrial encephalomyopathy and Leigh's disease. Two epileptic patients were studied as control subjects. Radioactivity was eliminated from the brain tissue of the epileptic patients soon after injection of pyruvate-1-11C. PET images of mitochondrial encephalomyopathy patients showed an increase in radioactivity in the cerebral cortex, basal ganglia and thalamus, with elimination of radioactivity being slower than that of epileptic patients. One patient with Leigh's disease showed similar PET images. PET using pyruvate-1-11C is useful for the evaluation of mitochondrial energy metabolism in the brain.

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Year:  1989        PMID： 2641450     DOI： 10.1007/bf03164593

Source DB:  PubMed          Journal:  Ann Nucl Med        ISSN： 0914-7187            Impact factor:   2.668


  25 in total

1.  Leigh's encephalomyelopathy in a patient with cytochrome c oxidase deficiency in muscle tissue.

Authors:  J L Willems; L A Monnens; J M Trijbels; J H Veerkamp; A E Meyer; K van Dam; U van Haelst
Journal:  Pediatrics       Date:  1977-12       Impact factor: 7.124

Review 2.  Carbohydrate homeostasis. I.

Authors:  R Levine; D E Haft
Journal:  N Engl J Med       Date:  1970-07-23       Impact factor: 91.245

3.  Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate.

Authors:  T Tsukiyama; T Hara; M Iio; G Kido; T Tsubokawa
Journal:  Eur J Nucl Med       Date:  1986

4.  Brain mitochondrial function after ischemia and hypoxia. I. Ischemia induced by increased intracranial pressure.

Authors:  H Schutz; P R Silverstein; M Vapalahti; D A Bruce; L Mela; T W Langfitt
Journal:  Arch Neurol       Date:  1973-12

5.  Glycolysis and epilepsy-induced changes in cerebrocortical NAD/NADH redox state.

Authors:  E Dóra
Journal:  J Neurochem       Date:  1983-12       Impact factor: 5.372

6.  Lactic acidosis and mitochondrial myopathy associated with deficiency of several components of complex III of the respiratory chain.

Authors:  N G Kennaway; N R Buist; V M Darley-Usmar; A Papadimitriou; S Dimauro; R I Kelley; R A Capaldi; N K Blank; A D'Agostino
Journal:  Pediatr Res       Date:  1984-10       Impact factor: 3.756

7.  Difference of 14C turnovers in brain and in transplanted glioma after intravenous injection of 14C-1-pyruvate into rats.

Authors:  T Hara; F Yokoi
Journal:  Eur J Nucl Med       Date:  1986

8.  Pyruvate dehydrogenase deficiency restricted to brain.

Authors:  M Prick; F Gabreëls; W Renier; F Trijbels; H Jaspar; K Lamers; J Kok
Journal:  Neurology       Date:  1981-04       Impact factor: 9.910

9.  Myoclonus epilepsy associated with ragged-red fibres (mitochondrial abnormalities ): disease entity or a syndrome? Light-and electron-microscopic studies of two cases and review of literature.

Authors:  N Fukuhara; S Tokiguchi; K Shirakawa; T Tsubaki
Journal:  J Neurol Sci       Date:  1980-07       Impact factor: 3.181

10.  Synthesis of pyruvate-1-11C as a radiopharmaceutical for tumor imaging.

Authors:  T Hara; M Iio; R Izuchi; T Tsukiyama; F Yokoi
Journal:  Eur J Nucl Med       Date:  1985
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