| Literature DB >> 25499432 |
Naoki Fukushima1, Naoya Ieda1, Mitsuyasu Kawaguchi1, Kiyoshi Sasakura2, Tetsuo Nagano2, Kenjiro Hanaoka2, Naoki Miyata1, Hidehiko Nakagawa1.
Abstract
Hydrogen sulfide (H2S) has multiple physiological roles, for example, in vasodilation and inflammation. It is a highly reactive gas under ambient conditions, so controllable H2S donors are required for studying its biological functions. Here, we describe the design, synthesis and application of a H2S donor (SPD-2) that utilizes xanthone photochemistry to control H2S release. H2S generation from SPD-2 was completely dependent on UVA-irradiation (325-385nm), as confirmed by methylene blue assay and by the use of a H2S-selective fluorescent probe. SPD-2 was confirmed to provide controlled H2S delivery in live cells, and should be suitable for various biological applications.Entities:
Keywords: Caged H(2)S; Hydrogen sulfide; Photolabile protecting group; Xanthone photocage
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Year: 2014 PMID： 25499432 DOI： 10.1016/j.bmcl.2014.11.084
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823