Eashita Das1,2, Joon Ho Moon1, Ju Hee Lee1,3, Nikita Thakkar1, Zdenka Pausova1,4, Hoon-Ki Sung5,6,7. 1. Translational Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 0A4, Canada. 2. Department of Microbiology, Siliguri College, North Bengal University, Siliguri, West Bengal, 734001, India. 3. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. 4. Department of Physiology, University of Toronto, Toronto, Canada. 5. Translational Medicine Program, The Hospital for Sick Children Research Institute, Toronto, Ontario, M5G 0A4, Canada. hoon-ki.sung@sickkids.ca. 6. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada. hoon-ki.sung@sickkids.ca. 7. Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada. hoon-ki.sung@sickkids.ca.
Abstract
PURPOSE OF REVIEW: Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN. RECENT FINDINGS: Adipose tissue provides mechanical protection of the blood vessels and plays a role in regulation of vascular tone. Exercise and fasting activate BAT and induce browning of white adipose tissue (WAT). BAT-secreted FGF21 lowers BP and protects against HTN. Browning of perivascular WAT improves HTN. New insights on WAT browning and BAT activation can open new avenues of potential therapeutic interventions to treat obesity-related HTN.
PURPOSE OF REVIEW: Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN. RECENT FINDINGS: Adipose tissue provides mechanical protection of the blood vessels and plays a role in regulation of vascular tone. Exercise and fasting activate BAT and induce browning of white adipose tissue (WAT). BAT-secreted FGF21 lowers BP and protects against HTN. Browning of perivascular WAT improves HTN. New insights on WAT browning and BAT activation can open new avenues of potential therapeutic interventions to treat obesity-related HTN.
Entities:
Keywords:
Batokine; Blood pressure and endothelial cells; Brown adipose tissue; Hypertension; Obesity
Authors: Patricia M Kearney; Megan Whelton; Kristi Reynolds; Paul Muntner; Paul K Whelton; Jiang He Journal: Lancet Date: 2005 Jan 15-21 Impact factor: 79.321
Authors: Evie P M Broeders; Guy H E J Vijgen; Bas Havekes; Nicole D Bouvy; Felix M Mottaghy; Marleen Kars; Nicolaas C Schaper; Patrick Schrauwen; Boudewijn Brans; Wouter D van Marken Lichtenbelt Journal: PLoS One Date: 2016-01-19 Impact factor: 3.240