Laura Kivelä1,2, Alina Popp1,3, Taina Arvola1,4, Heini Huhtala5, Katri Kaukinen6,7, Kalle Kurppa1. 1. Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland. 2. Department of Pediatrics, Hospital District of South Ostrobothnia, Seinäjoki, Finland. 3. Institute for Mother and Child Health Bucharest, University of Medicine and Pharmacy 'Carol Davila', Bucharest, Romania. 4. Department of Pediatrics, Hospital District of Kanta-Häme, Hämeenlinna, Finland. 5. Faculty of Social Sciences, University of Tampere, Tampere, Finland. 6. Department of Internal Medicine, Tampere University Hospital, Tampere, Finland. 7. Celiac Disease Research Center, University of Tampere, Tampere, Finland.
Abstract
BACKGROUND: The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. OBJECTIVE: To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. METHODS: After thorough evaluation of medical history, follow-up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis. The results were compared between screen-detected and clinically-detected patients, and also between originally asymptomatic and symptomatic screen-detected patients. RESULTS: In total, 236 (42%) patients completed the questionnaires a median of 18.5 years after childhood diagnosis. Screen-detected patients (n = 48) had coeliac disease in the family and type 1 diabetes more often, and were less often smokers and members of coeliac societies compared to clinically-detected patients, whereas the groups did not differ in current self-experienced health or health concerns, quality of life or dietary adherence. Screen-detected, originally asymptomatic patients had more anxiety than those presenting with symptoms, whereas the subgroups were comparable in other current characteristics. CONCLUSION: Comparable long-term outcomes between screen-detected and clinically-detected patients support risk-group screening for coeliac disease. However, asymptomatic patients may require special attention.
BACKGROUND: The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure. OBJECTIVE: To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening. METHODS: After thorough evaluation of medical history, follow-up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis. The results were compared between screen-detected and clinically-detected patients, and also between originally asymptomatic and symptomatic screen-detected patients. RESULTS: In total, 236 (42%) patients completed the questionnaires a median of 18.5 years after childhood diagnosis. Screen-detected patients (n = 48) had coeliac disease in the family and type 1 diabetes more often, and were less often smokers and members of coeliac societies compared to clinically-detected patients, whereas the groups did not differ in current self-experienced health or health concerns, quality of life or dietary adherence. Screen-detected, originally asymptomatic patients had more anxiety than those presenting with symptoms, whereas the subgroups were comparable in other current characteristics. CONCLUSION: Comparable long-term outcomes between screen-detected and clinically-detected patients support risk-group screening for coeliac disease. However, asymptomatic patients may require special attention.
Authors: F Casellas; L Rodrigo; J López Vivancos; S Riestra; C Pantiga; J S Baudet; F Junquera; V Puig Diví; C Abadia; M Papo; J Gelabert; J R Malagelada Journal: World J Gastroenterol Date: 2008-01-07 Impact factor: 5.742
Authors: SriHari Mahadev; Ruby Gardner; Suzanne K Lewis; Benjamin Lebwohl; Peter H Green Journal: J Clin Gastroenterol Date: 2016 May-Jun Impact factor: 3.062
Authors: Marisa G Stahl; Cristy Geno Rasmussen; Fran Dong; Kathleen Waugh; Jill M Norris; Judith Baxter; Liping Yu; Andrea K Steck; Brigitte I Frohnert; Edwin Liu; Marian J Rewers Journal: Am J Gastroenterol Date: 2021-01-01 Impact factor: 12.045
Authors: Lucas H P Bernts; David E J Jones; Marleen M Kaatee; Ansgar W Lohse; Christoph Schramm; Ekkehard Sturm; Joost P H Drenth Journal: Orphanet J Rare Dis Date: 2019-07-08 Impact factor: 4.123