Eric Rubenstein1, Laura Schieve2, Lisa Wiggins2, Catherine Rice3, Kim Van Naarden Braun2, Deborah Christensen2, Maureen Durkin4, Julie Daniels5, Li-Ching Lee6. 1. Department of Epidemiology, University of North Carolina at Chapel Hill, 116A South Merrit Mill, Chapel Hill, NC 27516, United States. Electronic address: erubenstein2@wisc.edu. 2. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS E-86, Atlanta, GA 30333, United States. 3. Department of Psychiatry, Emory University School of Medicine, 1551 Shoup Court, Atlanta, GA 30322, United States. 4. Department of Population Health Sciences, University of Wisconsin, 610 Walnut Street, Madison, WI 53726, United States. 5. Department of Epidemiology, University of North Carolina at Chapel Hill, 116A South Merrit Mill, Chapel Hill, NC 27516, United States. 6. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, United States.
Abstract
BACKGROUND: Autism spectrumdisorder (ASD) commonly presents with co-occurring medical conditions (CoCs). Little is known about patterns in CoCs in a time of rising ASD prevalence. AIMS: To describe trends in number and type of documented CoCs in 8-year-old children with ASD. METHODS: We used Autism and Developmental Disabilities Monitoring Network (ADDM) data, a multi-source active surveillance system monitoring ASD prevalence among 8-year-old children across the US. Data from surveillance years 2002, 2006, 2008, and 2010 were used to describe trends in count, categories, and individual CoCs. RESULTS: Mean number of CoCs increased from 0.94 CoCs in 2002 to 1.06 CoCs in 2010 (p < 0.001). The percentage of children with ASD with any CoC increased from 44.5% to 56.4% (p < 0.001). CoCs with the greatest increases were in general developmental disability (10.4% to 14.5%), language disorder (18.9% to 23.6%), and motor developmental disability (10.5% to 15.6%). Sex modified the relationship between developmental (P = 0.02) and psychiatric (P < 0.001) CoCs and surveillance year. Race/ethnicity modified the relationship between neurological conditions (P = 0.04) and surveillance year. CONCLUSIONS: The increase in the percentage of children with ASD and CoCs may suggest the ASD phenotype has changed over time or clinicians are more likely to diagnose CoCs.
BACKGROUND:Autism spectrumdisorder (ASD) commonly presents with co-occurring medical conditions (CoCs). Little is known about patterns in CoCs in a time of rising ASD prevalence. AIMS: To describe trends in number and type of documented CoCs in 8-year-old children with ASD. METHODS: We used Autism and Developmental Disabilities Monitoring Network (ADDM) data, a multi-source active surveillance system monitoring ASD prevalence among 8-year-old children across the US. Data from surveillance years 2002, 2006, 2008, and 2010 were used to describe trends in count, categories, and individual CoCs. RESULTS: Mean number of CoCs increased from 0.94 CoCs in 2002 to 1.06 CoCs in 2010 (p < 0.001). The percentage of children with ASD with any CoC increased from 44.5% to 56.4% (p < 0.001). CoCs with the greatest increases were in general developmental disability (10.4% to 14.5%), language disorder (18.9% to 23.6%), and motor developmental disability (10.5% to 15.6%). Sex modified the relationship between developmental (P = 0.02) and psychiatric (P < 0.001) CoCs and surveillance year. Race/ethnicity modified the relationship between neurological conditions (P = 0.04) and surveillance year. CONCLUSIONS: The increase in the percentage of children with ASD and CoCs may suggest the ASD phenotype has changed over time or clinicians are more likely to diagnose CoCs.
Authors: Amber M Angell; Deepthi S Varma; Alexis Deavenport-Saman; Larry Yin; Olga Solomon; Chen Bai; Baiming Zou Journal: Res Autism Spectr Disord Date: 2022-03-21
Authors: Eric Rubenstein; Deborah B Ehrenthal; Jenna Nobles; David C Mallinson; Lauren Bishop; Marina C Jenkins; Hsiang-Hui Kuo; Maureen S Durkin Journal: Disabil Health J Date: 2022-03-24 Impact factor: 4.615
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