BACKGROUND: We previously reported that an index of afterload-related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e'/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensive women. We aimed to determine sex-related differences in the E/e'-related indices for left ventricular diastolic function and their related factors during admission in patients with heart failure with preserved ejection fraction (HFpEF). HYPOTHESIS: Elderly HFpEF women exhibit severe left ventricular diastolic dysfunction associated with different left atrioventricular volume ratio. METHODS: We divided 267 patients with HFpEF (men/women, 116/151) into two groups by age (≥75 years, n = 212; <75 years, n = 55). We examined the alterations of E/e', E/e'/stroke volume index = Ed, and Ed/Ea, and cardiac structure during admission. RESULTS: Ed and Ea were significantly higher in women than in men, at admission, especially in patients ≥75 years. Before discharge, not only Ed and Ea but also Ed/Ea was significantly higher in women than in men, especially in patients ≥75 years. Elderly female patients had larger left atrial than left ventricular volume. CONCLUSIONS: Higher afterload-related left ventricular diastolic elastance, Ed/Ea, in association with higher arterial elastance, Ea, accompanied by left atrioventricular volume mismatch was observed in elderly HFpEF women.
BACKGROUND: We previously reported that an index of afterload-related left ventricular diastolic function, operant diastolic elastance (Ed)/effective arterial elastance (Ea) = E/e'/(0.9 × systolic blood pressure), was significantly higher in elderly hypertensivewomen. We aimed to determine sex-related differences in the E/e'-related indices for left ventricular diastolic function and their related factors during admission in patients with heart failure with preserved ejection fraction (HFpEF). HYPOTHESIS: Elderly HFpEF women exhibit severe left ventricular diastolic dysfunction associated with different left atrioventricular volume ratio. METHODS: We divided 267 patients with HFpEF (men/women, 116/151) into two groups by age (≥75 years, n = 212; <75 years, n = 55). We examined the alterations of E/e', E/e'/stroke volume index = Ed, and Ed/Ea, and cardiac structure during admission. RESULTS: Ed and Ea were significantly higher in women than in men, at admission, especially in patients ≥75 years. Before discharge, not only Ed and Ea but also Ed/Ea was significantly higher in women than in men, especially in patients ≥75 years. Elderly female patients had larger left atrial than left ventricular volume. CONCLUSIONS: Higher afterload-related left ventricular diastolic elastance, Ed/Ea, in association with higher arterial elastance, Ea, accompanied by left atrioventricular volume mismatch was observed in elderly HFpEF women.
Authors: Sherif F Nagueh; Christopher P Appleton; Thierry C Gillebert; Paolo N Marino; Jae K Oh; Otto A Smiseth; Alan D Waggoner; Frank A Flachskampf; Patricia A Pellikka; Arturo Evangelisa Journal: Eur J Echocardiogr Date: 2009-03
Authors: Margaret M Redfield; Steven J Jacobsen; Barry A Borlaug; Richard J Rodeheffer; David A Kass Journal: Circulation Date: 2005-10-03 Impact factor: 29.690
Authors: Mauro Gori; Carolyn S P Lam; Deepak K Gupta; Angela B S Santos; Susan Cheng; Amil M Shah; Brian Claggett; Michael R Zile; Elisabeth Kraigher-Krainer; Burkert Pieske; Adriaan A Voors; Milton Packer; Toni Bransford; Martin Lefkowitz; John J V McMurray; Scott D Solomon Journal: Eur J Heart Fail Date: 2014-02-23 Impact factor: 15.534
Authors: Willem B van Ham; Elise L Kessler; Marish I F J Oerlemans; M Louis Handoko; Joost P G Sluijter; Toon A B van Veen; Hester M den Ruijter; Saskia C A de Jager Journal: JACC Basic Transl Sci Date: 2022-05-25
Authors: Saraschandra Vallabhajosyula; Dhiran Verghese; Viral K Desai; Pranathi R Sundaragiri; Virginia M Miller Journal: Cardiovasc Res Date: 2022-02-21 Impact factor: 10.787