Ilwoo Park1,2, Janine M Lupo3, Sarah J Nelson3. 1. Department of Radiology, Chonnam National University Medical School, Jeabongro 42, Donggu, Gwangju, 61469, South Korea. ipark@jnu.ac.kr. 2. Department of Radiology, Chonnam National University Hospital, Gwangju, South Korea. ipark@jnu.ac.kr. 3. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA.
Abstract
PURPOSE: The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). PROCEDURES: C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-13C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA. Normalized lactate, pyruvate, total carbon, and lactate to pyruvate ratio from C-13 MRSI data were compared with normalized peak height and percent recovery of ΔR2* curve from the DSC images in the voxels containing tumor using a Pearson's linear correlation. RESULTS: Normalized peak height from DSC imaging showed substantial correlations with normalized lactate (r = 0.6, p = 0.02) and total carbon (r = 0.6, p = 0.02) from hyperpolarized C-13 MRSI data. CONCLUSIONS: Since the peak height in the ΔR2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.
PURPOSE: The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of humanglioblastoma multiforme (GBM). PROCEDURES: C-13 3D magnetic resonance spectroscopic imaging (MRSI) data were obtained from 14 tumor-bearing rats after the injection of hyperpolarized [1-13C]pyruvate at a 3T scanner. Dynamic susceptibility contrast (DSC) perfusion-weighted MR images were obtained following intravenous administration of Gd-DTPA. Normalized lactate, pyruvate, total carbon, and lactate to pyruvate ratio from C-13 MRSI data were compared with normalized peak height and percent recovery of ΔR2* curve from the DSC images in the voxels containing tumor using a Pearson's linear correlation. RESULTS: Normalized peak height from DSC imaging showed substantial correlations with normalized lactate (r = 0.6, p = 0.02) and total carbon (r = 0.6, p = 0.02) from hyperpolarized C-13 MRSI data. CONCLUSIONS: Since the peak height in the ΔR2* curve from DSC data is related to the extent of blood volume, these hyperpolarized C-13 imaging parameters may be used to assess blood volume in rodent intracranial xenograft models of GBM.
Authors: Ilwoo Park; Peder E Z Larson; Jeremy W Gordon; Lucas Carvajal; Hsin-Yu Chen; Robert Bok; Mark Van Criekinge; Marcus Ferrone; James B Slater; Duan Xu; John Kurhanewicz; Daniel B Vigneron; Susan Chang; Sarah J Nelson Journal: Magn Reson Med Date: 2018-01-10 Impact factor: 4.668
Authors: Ilwoo Park; Cornelius von Morze; Janine M Lupo; Jan H Ardenkjaer-Larsen; Achuta Kadambi; Daniel B Vigneron; Sarah J Nelson Journal: Magn Reson Med Date: 2016-02-19 Impact factor: 4.668
Authors: Ilwoo Park; Joydeep Mukherjee; Motokazu Ito; Myriam M Chaumeil; Llewellyn E Jalbert; Karin Gaensler; Sabrina M Ronen; Sarah J Nelson; Russell O Pieper Journal: Cancer Res Date: 2014-10-15 Impact factor: 12.701
Authors: Jan H Ardenkjaer-Larsen; Björn Fridlund; Andreas Gram; Georg Hansson; Lennart Hansson; Mathilde H Lerche; Rolf Servin; Mikkel Thaning; Klaes Golman Journal: Proc Natl Acad Sci U S A Date: 2003-08-20 Impact factor: 11.205
Authors: Ilwoo Park; Simon Hu; Robert Bok; Tomoko Ozawa; Motokazu Ito; Joydeep Mukherjee; Joanna J Phillips; C David James; Russell O Pieper; Sabrina M Ronen; Daniel B Vigneron; Sarah J Nelson Journal: Magn Reson Med Date: 2012-07-31 Impact factor: 4.668
Authors: Charles H Cunningham; Justin Y C Lau; Albert P Chen; Benjamin J Geraghty; William J Perks; Idan Roifman; Graham A Wright; Kim A Connelly Journal: Circ Res Date: 2016-09-15 Impact factor: 17.367
Authors: Jasmine Y Hu; Yaewon Kim; Adam W Autry; Mary M Frost; Robert A Bok; Javier E Villanueva-Meyer; Duan Xu; Yan Li; Peder E Z Larson; Daniel B Vigneron; Jeremy W Gordon Journal: Magn Reson Med Date: 2022-06-26 Impact factor: 3.737