Manabu Yamamoto1, Hiroaki Saito2, Chihiro Uejima1, Akimitsu Tanio1, Seigo Takaya1, Keigo Ashida1, Yoshiyuki Fujiwara1. 1. Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago, Japan. 2. Division of Surgical Oncology, Department of Surgery, School of Medicine, Tottori University Faculty of Medicine, Yonago, Japan, sai10@med.tottori-u.ac.jp.
Abstract
BACKGROUND: Although preoperative lymphopenia is reportedly a prognostic factor in cancer patients, the association between postoperative lymphopenia and patient prognosis has not been widely studied. METHODS: We enrolled 379 patients who underwent surgery for colorectal cancer (CRC) to analyze correlations among pre- and postoperative lymphocyte counts (LCs) and prognosis in patients with CRC. RESULTS: Pre- and postoperative LCs were significantly correlated (r = 0.615, p < 0.0001). Based on results of receiver operating characteristic analysis, patients were subgrouped as preoperative LC ≥1,280 (pre-LCHigh, n = 234), preoperative LC < 1,280 (pre-LCLow, n = 145); and as postoperative LC ≥680 (post-LCHigh, n = 246), and postoperative LC < 680 (post-LCLow, n = 133). Five-year disease-specific survival rates significantly differed between pre-LCHigh (88.6%) and pre-LCLow (72.5%) groups (p < 0.0001); and also between the post-LCHigh (88.5%) and post-LCLow (71.1%) groups (p < 0.0001). Five-year disease-specific survival rates of patients who were both pre-LCLow and post-LCLow was significantly lower than those for patients who were either pre-LCHigh or post-LCHigh or pre-LCHigh/post-LCHigh (p = 0.0003). Multivariate analysis indicated that the combination of pre- and postoperative LC was an independent prognostic indicator. CONCLUSIONS: The combination of pre- and postoperative LC is a predictive factor for prognosis in CRC patients.
BACKGROUND: Although preoperative lymphopenia is reportedly a prognostic factor in cancerpatients, the association between postoperative lymphopenia and patient prognosis has not been widely studied. METHODS: We enrolled 379 patients who underwent surgery for colorectal cancer (CRC) to analyze correlations among pre- and postoperative lymphocyte counts (LCs) and prognosis in patients with CRC. RESULTS: Pre- and postoperative LCs were significantly correlated (r = 0.615, p < 0.0001). Based on results of receiver operating characteristic analysis, patients were subgrouped as preoperative LC ≥1,280 (pre-LCHigh, n = 234), preoperative LC < 1,280 (pre-LCLow, n = 145); and as postoperative LC ≥680 (post-LCHigh, n = 246), and postoperative LC < 680 (post-LCLow, n = 133). Five-year disease-specific survival rates significantly differed between pre-LCHigh (88.6%) and pre-LCLow (72.5%) groups (p < 0.0001); and also between the post-LCHigh (88.5%) and post-LCLow (71.1%) groups (p < 0.0001). Five-year disease-specific survival rates of patients who were both pre-LCLow and post-LCLow was significantly lower than those for patients who were either pre-LCHigh or post-LCHigh or pre-LCHigh/post-LCHigh (p = 0.0003). Multivariate analysis indicated that the combination of pre- and postoperative LC was an independent prognostic indicator. CONCLUSIONS: The combination of pre- and postoperative LC is a predictive factor for prognosis in CRC patients.
Authors: Juan Carlos Andreu-Ballester; Lorena Galindo-Regal; Julia Hidalgo-Coloma; Carmen Cuéllar; Carlos García-Ballesteros; Carolina Hurtado; Natalia Uribe; María Del Carmen Martín; Ana Isabel Jiménez; Francisca López-Chuliá; Antonio Llombart-Cussac Journal: PLoS One Date: 2020-12-16 Impact factor: 3.240
Authors: Eric J Hsu; Jamie Thomas; Elizabeth A Maher; Michael Youssef; Robert D Timmerman; Zabi Wardak; Minjae Lee; Tu D Dan; Toral R Patel; Dat T Vo Journal: Front Oncol Date: 2022-09-09 Impact factor: 5.738