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Literature DB >> 30218369

X-Chromosome Inactivation and Escape from X Inactivation in Mouse.

Wenxiu Ma¹, Giancarlo Bonora², Joel B Berletch³, Xinxian Deng³, William S Noble², Christine M Disteche^4,5.

Abstract

X chromosome inactivation silences one X chromosome in female mammals. However, this silencing is incomplete, and some genes escape X inactivation. We describe methods to determine the chromosome-wide X inactivation status of genes in tissues or cell lines derived from mice using a combination of skewing of X inactivation and allele-specific analyses of gene expression based on RNA-seq.

Entities: Chemical Disease Gene Species

Keywords: Allelic gene expression; Escape from X inactivation; X inactivation

Mesh：

Year: 2018 PMID： 30218369 PMCID： PMC6269188 DOI： 10.1007/978-1-4939-8766-5_15

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

41 in total

1. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.

Authors: Yuko Hoki; Naomi Kimura; Minako Kanbayashi; Yuko Amakawa; Tatsuya Ohhata; Hiroyuki Sasaki; Takashi Sado
Journal: Development Date: 2008-11-26 Impact factor: 6.868

2. Escape from X inactivation of Smcx is preceded by silencing during mouse development.

Authors: P A Lingenfelter; D A Adler; D Poslinski; S Thomas; R W Elliott; V M Chapman; C M Disteche
Journal: Nat Genet Date: 1998-03 Impact factor: 38.330

3. X-inactivation profile reveals extensive variability in X-linked gene expression in females.

Authors: Laura Carrel; Huntington F Willard
Journal: Nature Date: 2005-03-17 Impact factor: 49.962

4. Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues.

Authors: Je Hyuk Lee; Evan R Daugharthy; Jonathan Scheiman; Reza Kalhor; Thomas C Ferrante; Richard Terry; Brian M Turczyk; Joyce L Yang; Ho Suk Lee; John Aach; Kun Zhang; George M Church
Journal: Nat Protoc Date: 2015-02-12 Impact factor: 13.491

5. Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta.

Authors: Elizabeth H Finn; Cheryl L Smith; Jesse Rodriguez; Arend Sidow; Julie C Baker
Journal: Dev Biol Date: 2014-03-02 Impact factor: 3.582

6. Global epigenomic reconfiguration during mammalian brain development.

Authors: Ryan Lister; Eran A Mukamel; Joseph R Nery; Mark Urich; Clare A Puddifoot; Nicholas D Johnson; Jacinta Lucero; Yun Huang; Andrew J Dwork; Matthew D Schultz; Miao Yu; Julian Tonti-Filippini; Holger Heyn; Shijun Hu; Joseph C Wu; Anjana Rao; Manel Esteller; Chuan He; Fatemeh G Haghighi; Terrence J Sejnowski; M Margarita Behrens; Joseph R Ecker
Journal: Science Date: 2013-07-04 Impact factor: 47.728

7. A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.

Authors: Shafagh Al Nadaf; Janine E Deakin; Clément Gilbert; Terence J Robinson; Jennifer A M Graves; Paul D Waters
Journal: Chromosoma Date: 2011-09-27 Impact factor: 4.316

X-Chromosome Inactivation and Escape from X Inactivation in Mouse.

1. A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.

2. Escape from X inactivation of Smcx is preceded by silencing during mouse development.

3. X-inactivation profile reveals extensive variability in X-linked gene expression in females.

4. Fluorescent in situ sequencing (FISSEQ) of RNA for gene expression profiling in intact cells and tissues.

5. Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta.

6. Global epigenomic reconfiguration during mammalian brain development.

7. A cross-species comparison of escape from X inactivation in Eutheria: implications for evolution of X chromosome inactivation.

8. Escape from X inactivation varies in mouse tissues.

9. HTSeq--a Python framework to work with high-throughput sequencing data.

10. Derivation of consensus inactivation status for X-linked genes from genome-wide studies.

1. Sex chromosome complement influences vulnerability to cocaine in mice.

Review 2. Sexual Dimorphism in Cardiovascular Biomarkers: Clinical and Research Implications.

3. Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19.