Literature DB >> 30211179

Hypertension genomics and cardiovascular prevention.

Fu Liang Ng1,2, Helen R Warren1, Mark J Caulfield1,2.   

Abstract

Hypertension continues to be a major risk factor for global mortality, and recent genome-wide association studies (GWAS) have expanded in size, leading to the identification of further genetic loci influencing blood pressure. In light of the new knowledge from the largest cardiovascular GWAS to date, we review the potential impact of genomics on discovering potential drug targets, risk stratification with genetic risk scores, drug selection with pharmacogenetics, and exploring insights provided by gene-environment interactions.

Entities:  

Keywords:  Hypertension; cardiovascular disease; gene-environment; genetics; pharmacogenetics; risk score

Year:  2018        PMID： 30211179      PMCID： PMC6123211          DOI： 10.21037/atm.2018.06.34

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN： 2305-5839


  105 in total

1.  Relationship between melatonin secretion and nighttime blood pressure in elderly individuals with and without antihypertensive treatment: a cross-sectional study of the HEIJO-KYO cohort.

Authors:  Kenji Obayashi; Keigo Saeki; Nobuhiro Tone; Norio Kurumatani
Journal:  Hypertens Res       Date:  2014-05-22       Impact factor: 3.872

2.  Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study.

Authors:  A G Vandell; C W McDonough; Y Gong; T Y Langaee; A M Lucas; A B Chapman; J G Gums; A L Beitelshees; K R Bailey; R J Johnson; E Boerwinkle; S T Turner; R M Cooper-DeHoff; J A Johnson
Journal:  J Intern Med       Date:  2014-02-28       Impact factor: 8.989

Review 3.  BCL2: A promising cancer therapeutic target.

Authors:  Gudapureddy Radha; Sathees C Raghavan
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-06-21       Impact factor: 10.680

4.  Autosomal recessive inheritance of human mitochondrial carbamyl phosphate synthetase deficiency.

Authors:  J W McReynolds; B Crowley; M J Mahoney; L E Rosenberg
Journal:  Am J Hum Genet       Date:  1981-05       Impact factor: 11.025

5.  Polymorphisms in the neurokinin-2 receptor gene are associated with angiotensin-converting enzyme inhibitor-induced cough.

Authors:  T-B Kim; S-Y Oh; H-K Park; S-G Jeon; Y-S Chang; K-Y Lee; Y S Cho; I-H Chae; Y-K Kim; S-H Cho; H-B Moon; K-U Min; Y-Y Kim
Journal:  J Clin Pharm Ther       Date:  2009-08       Impact factor: 2.512

6.  Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism and ACE inhibitor-related cough: a meta-analysis.

Authors:  Ya-Feng Li; Xiao-Ming Zhu; Fan Liu; Chuan-Shi Xiao; Yun-Fei Bian; Hong Li; Jun Cai; Rong-Shan Li; Xin-Chun Yang
Journal:  PLoS One       Date:  2012-06-19       Impact factor: 3.240

7.  Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.

Authors:  Fu Liang Ng; Ebbe Boedtkjer; Kate Witkowska; Meixia Ren; Ruoxin Zhang; Arthur Tucker; Christian Aalkjær; Mark J Caulfield; Shu Ye
Journal:  Hum Mol Genet       Date:  2017-03-01       Impact factor: 6.150

8.  Pleiotropic effect of common variants at ABO Glycosyltranferase locus in 9q32 on plasma levels of pancreatic lipase and angiotensin converting enzyme.

Authors: 
Journal:  PLoS One       Date:  2014-02-28       Impact factor: 3.240

9.  A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicity.

Authors:  Ruoxin Zhang; Kate Witkowska; José Afonso Guerra-Assunção; Meixia Ren; Fu Liang Ng; Claudio Mauro; Arthur T Tucker; Mark J Caulfield; Shu Ye
Journal:  Hum Mol Genet       Date:  2016-07-27       Impact factor: 6.150

10.  Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.

Authors:  Eleanor Wheeler; Aaron Leong; Ching-Ti Liu; Marie-France Hivert; Rona J Strawbridge; Clara Podmore; Man Li; Jie Yao; Xueling Sim; Jaeyoung Hong; Audrey Y Chu; Weihua Zhang; Xu Wang; Peng Chen; Nisa M Maruthur; Bianca C Porneala; Stephen J Sharp; Yucheng Jia; Edmond K Kabagambe; Li-Ching Chang; Wei-Min Chen; Cathy E Elks; Daniel S Evans; Qiao Fan; Franco Giulianini; Min Jin Go; Jouke-Jan Hottenga; Yao Hu; Anne U Jackson; Stavroula Kanoni; Young Jin Kim; Marcus E Kleber; Claes Ladenvall; Cecile Lecoeur; Sing-Hui Lim; Yingchang Lu; Anubha Mahajan; Carola Marzi; Mike A Nalls; Pau Navarro; Ilja M Nolte; Lynda M Rose; Denis V Rybin; Serena Sanna; Yuan Shi; Daniel O Stram; Fumihiko Takeuchi; Shu Pei Tan; Peter J van der Most; Jana V Van Vliet-Ostaptchouk; Andrew Wong; Loic Yengo; Wanting Zhao; Anuj Goel; Maria Teresa Martinez Larrad; Dörte Radke; Perttu Salo; Toshiko Tanaka; Erik P A van Iperen; Goncalo Abecasis; Saima Afaq; Behrooz Z Alizadeh; Alain G Bertoni; Amelie Bonnefond; Yvonne Böttcher; Erwin P Bottinger; Harry Campbell; Olga D Carlson; Chien-Hsiun Chen; Yoon Shin Cho; W Timothy Garvey; Christian Gieger; Mark O Goodarzi; Harald Grallert; Anders Hamsten; Catharina A Hartman; Christian Herder; Chao Agnes Hsiung; Jie Huang; Michiya Igase; Masato Isono; Tomohiro Katsuya; Chiea-Chuen Khor; Wieland Kiess; Katsuhiko Kohara; Peter Kovacs; Juyoung Lee; Wen-Jane Lee; Benjamin Lehne; Huaixing Li; Jianjun Liu; Stephane Lobbens; Jian'an Luan; Valeriya Lyssenko; Thomas Meitinger; Tetsuro Miki; Iva Miljkovic; Sanghoon Moon; Antonella Mulas; Gabriele Müller; Martina Müller-Nurasyid; Ramaiah Nagaraja; Matthias Nauck; James S Pankow; Ozren Polasek; Inga Prokopenko; Paula S Ramos; Laura Rasmussen-Torvik; Wolfgang Rathmann; Stephen S Rich; Neil R Robertson; Michael Roden; Ronan Roussel; Igor Rudan; Robert A Scott; William R Scott; Bengt Sennblad; David S Siscovick; Konstantin Strauch; Liang Sun; Morris Swertz; Salman M Tajuddin; Kent D Taylor; Yik-Ying Teo; Yih Chung Tham; Anke Tönjes; Nicholas J Wareham; Gonneke Willemsen; Tom Wilsgaard; Aroon D Hingorani; Josephine Egan; Luigi Ferrucci; G Kees Hovingh; Antti Jula; Mika Kivimaki; Meena Kumari; Inger Njølstad; Colin N A Palmer; Manuel Serrano Ríos; Michael Stumvoll; Hugh Watkins; Tin Aung; Matthias Blüher; Michael Boehnke; Dorret I Boomsma; Stefan R Bornstein; John C Chambers; Daniel I Chasman; Yii-Der Ida Chen; Yduan-Tsong Chen; Ching-Yu Cheng; Francesco Cucca; Eco J C de Geus; Panos Deloukas; Michele K Evans; Myriam Fornage; Yechiel Friedlander; Philippe Froguel; Leif Groop; Myron D Gross; Tamara B Harris; Caroline Hayward; Chew-Kiat Heng; Erik Ingelsson; Norihiro Kato; Bong-Jo Kim; Woon-Puay Koh; Jaspal S Kooner; Antje Körner; Diana Kuh; Johanna Kuusisto; Markku Laakso; Xu Lin; Yongmei Liu; Ruth J F Loos; Patrik K E Magnusson; Winfried März; Mark I McCarthy; Albertine J Oldehinkel; Ken K Ong; Nancy L Pedersen; Mark A Pereira; Annette Peters; Paul M Ridker; Charumathi Sabanayagam; Michele Sale; Danish Saleheen; Juha Saltevo; Peter Eh Schwarz; Wayne H H Sheu; Harold Snieder; Timothy D Spector; Yasuharu Tabara; Jaakko Tuomilehto; Rob M van Dam; James G Wilson; James F Wilson; Bruce H R Wolffenbuttel; Tien Yin Wong; Jer-Yuarn Wu; Jian-Min Yuan; Alan B Zonderman; Nicole Soranzo; Xiuqing Guo; David J Roberts; Jose C Florez; Robert Sladek; Josée Dupuis; Andrew P Morris; E-Shyong Tai; Elizabeth Selvin; Jerome I Rotter; Claudia Langenberg; Inês Barroso; James B Meigs
Journal:  PLoS Med       Date:  2017-09-12       Impact factor: 11.069
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  8 in total

Review 1.  Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated.

Authors:  Claudia P Cabrera; Fu Liang Ng; Hannah L Nicholls; Ajay Gupta; Michael R Barnes; Patricia B Munroe; Mark J Caulfield
Journal:  Hum Mol Genet       Date:  2019-11-21       Impact factor: 6.150

2.  Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes.

Authors:  Saebom Jeon; Ji-Yeon Shin; Jaeyong Yee; Taesung Park; Mira Park
Journal:  PLoS One       Date:  2019-09-12       Impact factor: 3.240

3.  The contribution of non-coding regulatory elements to cardiovascular disease.

Authors:  Diego Villar; Stephanie Frost; Panos Deloukas; Andrew Tinker
Journal:  Open Biol       Date:  2020-07-01       Impact factor: 6.411

4.  p38/JNK Is Required for the Proliferation and Phenotype Changes of Vascular Smooth Muscle Cells Induced by L3MBTL4 in Essential Hypertension.

Authors:  Chaowei Hu; Kun Zuo; Kuibao Li; Yuanfeng Gao; Mulei Chen; Roumu Hu; Ye Liu; Hongjie Chi; Hongjiang Wang; Yanwen Qin; Xiaoyan Liu; Jiuchang Zhong; Jun Cai; Xinchun Yang; Jing Li
Journal:  Int J Hypertens       Date:  2020-12-16       Impact factor: 2.420

Review 5.  Mosaic theory revised: inflammation and salt play central roles in arterial hypertension.

Authors:  Felicitas E Hengel; Jean-Pierre Benitah; Ulrich O Wenzel
Journal:  Cell Mol Immunol       Date:  2022-03-30       Impact factor: 22.096

Review 6.  Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?

Authors:  Meena S Madhur; Fernando Elijovich; Matthew R Alexander; Ashley Pitzer; Jeanne Ishimwe; Justin P Van Beusecum; David M Patrick; Charles D Smart; Thomas R Kleyman; Justin Kingery; Robert N Peck; Cheryl L Laffer; Annet Kirabo
Journal:  Circ Res       Date:  2021-04-01       Impact factor: 17.367

7.  TRIB3 rs6037475 is a potential biomarker for predicting felodipine drug response in Chinese patients with hypertension.

Authors:  Fazhong He; Bao Sun; Ling Li; Mouze Liu; Weijie Lin; Lin Liu; Yinxiang Sun; Yuhong Luo; Lin Wu; Ligong Lu; Wei Zhang; Zhiling Zhou
Journal:  Ann Transl Med       Date:  2020-04

8.  First genome-wide association study investigating blood pressure and renal traits in domestic cats.

Authors:  R E Jepson; H Warren; M D Wallace; H M Syme; J Elliott; P B Munroe
Journal:  Sci Rep       Date:  2022-02-03       Impact factor: 4.379
  8 in total

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